Harris Stephanie, McMichael Maureen A, Harmon Roy, Boothe Dawn
Department of Clinical Sciences, Auburn University College of Veterinary Medicine, Auburn, AL, United States.
Department of Anatomy, Physiology and Pharmacology, Auburn University College of Veterinary Medicine, Auburn, AL, United States.
Front Vet Sci. 2022 Jul 12;9:938021. doi: 10.3389/fvets.2022.938021. eCollection 2022.
A 4-year-old, female-spayed, mixed breed dog, weighing 24.2 kg, was presented for acute ingestion of ~12.3 mg/kg of Adderall XR, an extended-release amphetamine medication. In dogs, the oral median lethal dose for amphetamines ranges anywhere from 9-11 mg/kg to 20-27 mg/kg. On presentation, the patient was agitated, tachycardic and hypertensive. Initial treatment was instituted with intravenous lipid emulsion (IVLE) therapy, and baseline and post-treatment amphetamine concentrations were quantified in serum and plasma. In both serum and plasma, post-IVLE concentrations of amphetamine were lower 1 h after treatment and IVLE was the only treatment instituted during this time. The dog improved significantly while in hospital and was discharged <24 h after presentation. This is the first known reported use of IVLE for treatment of amphetamine toxicosis with documented decreases in both serum and plasma amphetamine levels shortly after administration of IVLE.
一只4岁、已绝育的雌性混种犬，体重24.2千克，因急性摄入约12.3毫克/千克的安非他命缓释剂（一种缓释苯丙胺药物）前来就诊。在犬类中，苯丙胺的口服半数致死剂量范围为9 - 11毫克/千克至20 - 27毫克/千克。就诊时，该患者烦躁不安、心动过速且血压升高。初始治疗采用静脉注射脂质乳剂（IVLE）疗法，并对血清和血浆中的苯丙胺基线浓度及治疗后浓度进行了定量分析。在血清和血浆中，治疗后1小时苯丙胺的IVLE浓度均降低，且在此期间仅采用了IVLE治疗。这只狗在住院期间病情显著改善，并在就诊后不到24小时出院。这是首次有已知报道使用IVLE治疗苯丙胺中毒，且有记录显示在给予IVLE后不久血清和血浆中的苯丙胺水平均有所下降。
