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一项前瞻性观察性研究,旨在评估卢瓦尔河婴儿随访团队(LIFT队列)中极早产儿童的依恋表征与神经认知和行为结果的关系。

A Prospective Observational Study to Assess Attachment Representations With Regard to Neurocognitive and Behavioral Outcomes in Children Born Very Prematurely in the Loire Infant Follow-Up Team (LIFT Cohort).

作者信息

Riquin Elise, Sandnes Ramona, Bacro Fabien, Vinay Aubeline, Miljkovitch Raphaële, Rouger Valérie, Rakotonjanahary Josué, Gascoin Géraldine, Müller Jean-Baptiste

机构信息

Department of Child and Adolescent Psychiatry, University Hospital of Angers, Angers, France.

CHU Angers, University of Angers, Angers, France.

出版信息

Front Pediatr. 2022 Jul 13;10:896103. doi: 10.3389/fped.2022.896103. eCollection 2022.

DOI:10.3389/fped.2022.896103
PMID:35903159
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9315259/
Abstract

CONTEXT AND PURPOSE

Prematurity is a situation that can disrupt parent-child interactions. We hypothesize that establishing relationships with parents in a context of extreme prematurity can alter the development of secure attachment representations in the child. Furthermore, we hypothesize that secure maternal representations and their possible interactions with prematurity factors prevent the development of insecure or disorganized attachment in the child. In addition, maternal representations and their possible interactions with factors related to prematurity may prevent or accentuate the development of an insecure or disorganized attachment in the child.

METHODS AND ANALYSIS

This is a longitudinal, prospective, exploratory, and bi-centric study. Children born in the neonatal intensive care units of Angers or Nantes University Hospitals with a gestational age of up to 28 weeks will be included in the study. The main objective is to describe the attachment representations at 3 and 5 years through the Attachment Story Completion Task scales and to analyze them in regard to the children's neurocognitive and behavioral outcomes as well as maternal attachment and mental health.

ETHICS

The study file received a favorable opinion for the implementation of this research on February 18, 2020 - ID-RCB no. 2019-A03352-55 (File 2-20-007 id6699) 2°HPS. This study has received authorization from the French Data Protection Authority (CNIL) under no. 920229.

DISCUSSION

A better understanding of attachment representations in extreme prematurity and their possible associations with children's neurocognitive and behavioral outcomes as well as maternal attachment and mental health could pave the way for individualized care at an early stage, or even interventions during the neonatal period to improve the outcome of these vulnerable newborns.

TRIAL REGISTRATION

[ClinicalTrials.gov], identifier [NCT04304846].

摘要

背景与目的

早产是一种可能会干扰亲子互动的情况。我们假设,在极端早产的情况下与父母建立关系可以改变儿童安全依恋表征的发展。此外,我们假设安全的母亲表征及其与早产因素的可能相互作用可防止儿童形成不安全或混乱的依恋。此外,母亲表征及其与早产相关因素的可能相互作用可能会防止或加剧儿童不安全或混乱依恋的发展。

方法与分析

这是一项纵向、前瞻性、探索性的双中心研究。纳入在昂热或南特大学医院新生儿重症监护病房出生、胎龄达28周的儿童。主要目的是通过依恋故事完成任务量表描述3岁和5岁时的依恋表征,并根据儿童的神经认知和行为结果以及母亲的依恋和心理健康状况对其进行分析。

伦理

该研究文件于2020年2月18日获得了开展本研究的有利意见——ID-RCB编号2019-A03352-55(文件2-20-007 id6699)2°HPS。本研究已获得法国数据保护局(CNIL)编号为920229的授权。

讨论

更好地理解极端早产中的依恋表征及其与儿童神经认知和行为结果以及母亲依恋和心理健康的可能关联,可为早期个性化护理甚至新生儿期干预铺平道路,以改善这些脆弱新生儿的结局。

试验注册

[ClinicalTrials.gov],标识符[NCT04304846]。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f575/9315259/99dc82177b95/fped-10-896103-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f575/9315259/793cde2f5130/fped-10-896103-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f575/9315259/99dc82177b95/fped-10-896103-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f575/9315259/793cde2f5130/fped-10-896103-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f575/9315259/99dc82177b95/fped-10-896103-g002.jpg

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本文引用的文献

1
Mothers' Attachment Representations and Children's Brain Structure.母亲的依恋表征与儿童的脑结构
Front Hum Neurosci. 2022 Mar 16;16:740195. doi: 10.3389/fnhum.2022.740195. eCollection 2022.
2
Mother-infant interaction assessment at discharge and at 6 months in a French cohort of infants born very preterm: The OLIMPE study.法国极早产儿队列出院时及6个月时母婴互动评估:OLIMPE研究。
PLoS One. 2017 Dec 7;12(12):e0188942. doi: 10.1371/journal.pone.0188942. eCollection 2017.
3
Cohort Profile: Longitudinal study of preterm infants in the Pays de la Loire region of France (LIFT cohort).
队列简介:法国卢瓦尔河地区早产儿纵向研究(LIFT队列)。
Int J Epidemiol. 2017 Oct 1;46(5):1396-1397h. doi: 10.1093/ije/dyx110.
4
Triadic interactions in families with preterm children: a comparative study with children born at term.早产儿童家庭中的三元互动:与足月儿出生儿童的比较研究。
Neuropsychiatr Dis Treat. 2017 Sep 13;13:2375-2388. doi: 10.2147/NDT.S129225. eCollection 2017.
5
Narrowing the transmission gap: A synthesis of three decades of research on intergenerational transmission of attachment.缩小传递差距:对依恋的代际传递进行三十年研究的综合。
Psychol Bull. 2016 Apr;142(4):337-366. doi: 10.1037/bul0000038. Epub 2015 Dec 14.
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Pilot Studies: A Critical but Potentially Misused Component of Interventional Research.试点研究:介入性研究中一个关键但可能被滥用的组成部分。
JAMA. 2015 Oct 20;314(15):1561-2. doi: 10.1001/jama.2015.10962.
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Refining the assessment of internal working models: the Attachment Multiple Model Interview.完善内部工作模式评估:依恋多重模型访谈
Attach Hum Dev. 2015;17(5):492-521. doi: 10.1080/14616734.2015.1075561. Epub 2015 Sep 1.
8
Caregiving antecedents of secure base script knowledge: a comparative analysis of young adult attachment representations.安全基地脚本知识的照顾经历前因:对青年成人依恋表征的比较分析
Dev Psychol. 2014 Nov;50(11):2526-2538. doi: 10.1037/a0037992. Epub 2014 Sep 29.
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Pers Soc Psychol Rev. 2015 Feb;19(1):44-76. doi: 10.1177/1088868314541858. Epub 2014 Jul 14.
10
Sample size requirements to estimate key design parameters from external pilot randomised controlled trials: a simulation study.从外部试点随机对照试验估计关键设计参数所需的样本量:一项模拟研究。
Trials. 2014 Jul 3;15:264. doi: 10.1186/1745-6215-15-264.