一项队列研究评估 CT 灌注成像在化疗后转移性骨肉瘤患者中的疗效和价值。

A Cohort Study to Evaluate the Efficacy and Value of CT Perfusion Imaging in Patients with Metastatic Osteosarcoma after Chemotherapy.

机构信息

CT Diagnosis Department, Cangzhou Central Hospital, Cangzhou City, Hebei Province 061001, China.

Department of Critical Medicine, Cangzhou Central Hospital, Cangzhou City, Hebei Province 061001, China.

出版信息

Comput Math Methods Med. 2022 Jul 19;2022:5417753. doi: 10.1155/2022/5417753. eCollection 2022.

DOI:10.1155/2022/5417753

PMID:35903433

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9325339/

Abstract

OBJECTIVE

A case-control study was conducted to explore the efficacy of cohort study and value of CT perfusion imaging in patients with metastatic osteosarcoma after chemotherapy.

METHODS

Eighty patients with metastatic osteosarcoma treated in our hospital from March 2020 to December 2021 were divided into two groups. According to their different treatment methods, the chemotherapy+antiangiogenesis group had 36 cases and the chemotherapy group had 44 cases. All patients were scanned by 64-slice spiral CT before and after treatment. The differences of tumor volume and perfusion parameters before and after treatment were compared, and the correlation between perfusion parameters and tumor microvessel density (MVD) was analyzed. The receiver working curve (ROC curve) was used to evaluate the efficacy of the two groups after chemotherapy.

RESULTS

Blood flow (BF), blood volume (BV), Pallak blood volume (PBV), and time to start (TTS) in the antitumor angiogenesis+chemotherapy group were significantly lower than those before treatment ( < 0.05). Microvessel density was positively correlated with PS, BF, BV, and PBV ( < 0.05). The reduction rate of BV and BF in the remission group after treatment was significantly higher than that in the nonremission group. When the BV and BF decline rates were 47.37% and 21.53% and the areas under the curve were 0.968 and 0.916, respectively, the diagnostic effect was the best. When the decrease rate of BV was 47.48% and the decrease rate of BF was 21.55%, the sensitivity was 94.72% and 89.56% and the specificity was 91.31% and 91.31%.

CONCLUSION

The reduction rate of BV and BF in CT perfusion imaging is of high value in evaluating the efficacy of radiotherapy and chemotherapy in patients with NSCLC and can provide more objective basis for observing the changes and judging the prognosis of osteosarcoma after treatment.

摘要

目的

采用病例对照研究探讨队列研究和 CT 灌注成像在化疗后转移性骨肉瘤患者中的疗效。

方法

选取 2020 年 3 月至 2021 年 12 月在我院治疗的 80 例转移性骨肉瘤患者，按照治疗方法的不同分为化疗+抗血管生成组 36 例和化疗组 44 例。所有患者治疗前后均采用 64 层螺旋 CT 扫描，比较治疗前后肿瘤体积及灌注参数差异，分析灌注参数与肿瘤微血管密度（MVD）的相关性，采用受试者工作曲线（ROC 曲线）评估两组化疗后的疗效。

结果

抗肿瘤血管生成+化疗组的血流量（BF）、血容量（BV）、血容量比（PBV）和达峰时间（TTS）均明显低于治疗前（<0.05），MVD 与 PS、BF、BV、PBV 呈正相关（<0.05）。治疗后缓解组的 BV 和 BF 下降率明显高于未缓解组，BV 和 BF 下降率分别为 47.37%和 21.53%，曲线下面积分别为 0.968 和 0.916，诊断效果最佳。当 BV 下降率为 47.48%、BF 下降率为 21.55%时，灵敏度分别为 94.72%和 89.56%，特异度分别为 91.31%和 91.31%。