Zhao L, Guan W, Han Y, Zhao Y
Department of Radiology, First Affiliated Hospital of Henan University of Science and Technology, Henan University of Science and Technology, Luoyang, China.
Department of Nuclear Medicine, First Affiliated hospital of Henan University of Science and Technology, Henan University of Science and Technology, Luoyang, China.
J Biol Regul Homeost Agents. 2014 Oct-Dec;28(4):675-81.
The aim of this paper was to observe the changes in computed tomography (CT) perfusion parameters of patients with lung cancer in early stage before and after chemoradiotherapy. Twenty-five previously treated lung cancer patients underwent a first CT perfusion scan and then a following one before the second course of chemotherapy. CT images of the fourth course of treatment were compared with the initial images. The cases were divided into a remission group and a non-remission group according to Response Evaluation Criteria In Solid Tumors (RECIST). Blood flow (BF), blood volume (BV), Patlak permeability Surface (PS) and Pallak blood volume (PBV) in the different groups were respectively compared before and after treatment. In addition, SPSS17.0 was applied for statistical analysis. P less than 0.05 signified that the difference had statistical meaning. CT perfusion parameters were all found to be changed compared to before the treatment. BV and PBV parameters decreased twice. BV and PBV parameters in the non-remission group showed an increasing trend. The difference before and after the treatment of these parameters had the highest statistical significance, as well as the difference of remission rate of PBV increasing group and decreasing group. Through the contrasting χ2 test of remission rate of BV and PBV, it was found that the remission rate of the BV increasing group and the decreasing group had no statistical difference; the remission rate in the PBV decreasing group was higher than the increasing group. All the findings suggest that the change in size of the damaged tissue had no statistical meaning in the early stage of CT perfusion parameter change; CT perfusion parameter of the remission group in the early stage after chemotherapy decreased while the non-remission group increased; the change of BV and PBV was significant.
本文旨在观察早期肺癌患者放化疗前后的计算机断层扫描（CT）灌注参数变化。25例既往接受过治疗的肺癌患者在第二个化疗疗程前进行了首次CT灌注扫描，随后又进行了一次扫描。将第四个疗程的CT图像与初始图像进行比较。根据实体瘤疗效评价标准（RECIST）将病例分为缓解组和非缓解组。分别比较不同组治疗前后的血流量（BF）、血容量（BV）、Patlak通透表面积（PS）和Pallak血容量（PBV）。此外，应用SPSS17.0进行统计分析。P值小于0.05表示差异具有统计学意义。结果发现，与治疗前相比，CT灌注参数均发生了变化。BV和PBV参数两次下降。非缓解组的BV和PBV参数呈上升趋势。这些参数治疗前后的差异具有最高的统计学意义，PBV升高组和降低组的缓解率差异也具有统计学意义。通过对BV和PBV缓解率的对比χ2检验，发现BV升高组和降低组的缓解率无统计学差异；PBV降低组的缓解率高于升高组。所有研究结果表明，在CT灌注参数变化的早期，受损组织大小的变化无统计学意义；化疗后早期缓解组的CT灌注参数下降而非缓解组上升；BV和PBV的变化显著。
