Poudel Prakar, Chalasani Roopa, Goonathilake Mastiyage R, Waqar Sara, George Sheeba, Jean-Baptiste Wilford, Yusuf Ali Amina, Inyang Bithaiah, Koshy Feeba Sam, George Kitty, Mohammed Lubna
Research, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.
Cureus. 2022 Jun 26;14(6):e26353. doi: 10.7759/cureus.26353. eCollection 2022 Jun.
The effect of thyroid hormones on bone mineral density in postmenopausal women has been reported but is not completely established. To better understand this relationship, this systematic review of the reported association, differences, and effects of thyroxine and/or thyrotropin levels on bone mineral density was conducted. An electronic literature search was conducted on MEDLINE, PMC, Google Scholar, Cochrane Library, and Science Direct from inception to April 2022; 20 studies were identified which include five quasi-experimental studies, three community cohort studies, and 12 hospital-based cross-sectional studies. Following an extensive evaluation, it was difficult to conclusively determine the association or effect of thyroxine or thyrotropin levels on bone mineral density in postmenopausal women. It is therefore suggested to conduct additional non-randomized or randomized control studies on this topic for the benefit of postmenopausal women. Particular attention should be given to the adjustment of age, body mass index, smoking status, alcohol consumption, and dietary calcium in future research on this topic for rigorous analysis.
甲状腺激素对绝经后女性骨密度的影响已有报道，但尚未完全明确。为了更好地理解这种关系，我们对已报道的甲状腺素和/或促甲状腺激素水平与骨密度之间的关联、差异及影响进行了系统综述。从创刊至2022年4月，我们在MEDLINE、PMC、谷歌学术、考克兰图书馆和科学直投数据库进行了电子文献检索；共识别出20项研究，其中包括5项准实验研究、3项社区队列研究和12项基于医院的横断面研究。经过广泛评估，很难最终确定甲状腺素或促甲状腺激素水平与绝经后女性骨密度之间的关联或影响。因此，建议针对这一主题开展更多非随机或随机对照研究，以造福绝经后女性。在今后关于该主题的研究中，应特别注意对年龄、体重指数、吸烟状况、饮酒量和膳食钙进行调整，以便进行严谨分析。
