Pavithran Priyanka, Sudarshan Pramod K, Eliyas Salin, Sekhar Biju, Kaniachallil Kishore
Department of Anaesthesiology, ASTER MIMS, Calicut, Kerala, India.
Department of Spine Surgery, ASTER MIMS, Calicut, Kerala, India.
Indian J Anaesth. 2022 Jun;66(6):436-441. doi: 10.4103/ija.ija_1054_21. Epub 2022 Jun 21.
Posterior lumbar spine fusion surgeries are associated with severe postoperative pain necessitating a multimodal analgesic regime. Wound infiltration with local anaesthetic is an accepted modality for postoperative analgesia in spine surgeries. Thoracolumbar interfascial plane (TLIP) block is a novel technique being evaluated for providing analgesia in lumbar spine surgeries. This study aimed to compare the analgesic efficacy of TLIP block compared to that of wound infiltration with local anaesthetic in terms of time to request the first dose of rescue analgesic.
Seventy-one patients scheduled for posterior lumbar spine fusion under general anaesthesia were included in this double-blinded randomised controlled trial. Preoperatively, patients were randomly allocated to receive either a TLIP block (TLIP group) or wound infiltration (LI group). The primary endpoint was the time of the first request for rescue analgesia. Secondary endpoints were the total tramadol consumption and pain and comfort scores measured at various time points in the 48-h postoperative period. The trial was terminated after second interim analysis as the analgesic benefit of TLIP was evident both clinically and statistically.
The median (interquartile range) duration of the time of the first request for rescue analgesia was 1440 (1290, 2280) min in the TLIP group and 340 (180, 360) min in the infiltration group; value <.001. The mean tramadol consumption was significantly higher in the infiltration group compared to the TLIP group, with a value <.001.
TLIP block provided better postoperative analgesia than that provided by wound infiltration with local anaesthetic.
腰椎后路融合手术会导致严重的术后疼痛,因此需要采用多模式镇痛方案。伤口局部麻醉浸润是脊柱手术中一种公认的术后镇痛方式。胸腰筋膜平面(TLIP)阻滞是一种正在评估的用于腰椎手术镇痛的新技术。本研究旨在比较TLIP阻滞与伤口局部麻醉浸润在首次要求使用急救镇痛药时间方面的镇痛效果。
本双盲随机对照试验纳入了71例计划在全身麻醉下进行腰椎后路融合手术的患者。术前,患者被随机分配接受TLIP阻滞(TLIP组)或伤口浸润(LI组)。主要终点是首次要求使用急救镇痛药的时间。次要终点是术后48小时内各个时间点的曲马多总消耗量以及疼痛和舒适度评分。由于TLIP的镇痛益处在临床和统计学上均很明显,第二次中期分析后试验终止。
TLIP组首次要求使用急救镇痛药的时间中位数(四分位间距)为1440(1290,2280)分钟,浸润组为340(180,360)分钟;P值<.001。浸润组的曲马多平均消耗量显著高于TLIP组,P值<.001。
TLIP阻滞提供的术后镇痛效果优于伤口局部麻醉浸润。