Wang Jingjing, Wu Ruolin, Liu Fang, Yang Liu, Hu Fan, Wu Zhijian, Gao Zairong, Xia Xiaotian
Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China.
Front Oncol. 2022 Jul 12;12:925382. doi: 10.3389/fonc.2022.925382. eCollection 2022.
Cutaneous and subcutaneous soft tissue metastases are rare in lung adenocarcinoma and suggest poor prognosis. We report a patient with lung adenocarcinoma who initially presented with cutaneous and subcutaneous metastases to the abdomen that were initially presumed to be herpes zoster and an occult subcutaneous soft tissue mass. Because the lesions progressed over 3 weeks despite routine herpes zoster treatment, magnetic resonance imaging was performed and showed a presumed sarcoma; however, F-fluourodeoxyglucose positron emission tomography/computed tomography demonstrated pulmonary lesions. Biopsy of the abdominal lesion confirmed poorly differentiated lung adenocarcinoma. Early diagnosis of soft tissue metastasis can be difficult. Clinicians should suspect internal organ malignancy when a progressive cutaneous or subcutaneous soft tissue lesion is encountered.
皮肤和皮下软组织转移在肺腺癌中较为罕见，提示预后不良。我们报告1例肺腺癌患者，最初表现为腹部皮肤和皮下转移，最初被误诊为带状疱疹及隐匿性皮下软组织肿块。尽管进行了常规的带状疱疹治疗，病变仍在3周内进展，于是进行了磁共振成像检查，结果显示为疑似肉瘤；然而，氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描显示肺部有病变。腹部病变活检确诊为低分化肺腺癌。软组织转移的早期诊断可能存在困难。当遇到进行性皮肤或皮下软组织病变时，临床医生应怀疑存在内脏恶性肿瘤。
