Otto U, Huland H, Klöppel G, Baisch H
Urol Int. 1987;42(1):1-5. doi: 10.1159/000281841.
128 tumors from three different human renal-cell carcinomas and from one human transitional bladder cancer were transplanted into NMRI mice treated with cyclosporin A at various dosages. Their acceptance rate, proliferation rate, and morphologic and growth characteristics were studied and compared with those of the same human tumors after transplantation into NMRI nu/nu mice. The acceptance rate was 80% in mice treated with cyclosporin A at 100 mg/kg-1 and 150 mg/kg-1/day. The highest acceptance rate was observed after transplantation into nu/nu (thymus-aplastic) mice (100%). Morphologically, the transplanted tumor was similar in the two animal groups and identical with the primary tumors. Metastases were not seen in either animal model. The NMRI mice treated with cyclosporin A had leukocyte infiltration into the transplanted tumor. The growth rate of the human tumors in normal mice depended on the cyclosporin A dosage, and was highest in the nu/nu mice. The proliferation rates of the transplanted human tumors, as judged by flow cytometry, were rather similar in all groups.
将来自三种不同类型人类肾细胞癌的128个肿瘤以及1个人类移行性膀胱癌肿瘤移植到用不同剂量环孢素A处理的NMRI小鼠体内。研究了它们的接受率、增殖率以及形态学和生长特征，并与这些人类肿瘤移植到NMRI裸鼠后的情况进行比较。在用100mg/kg-1和150mg/kg-1/天的环孢素A处理的小鼠中，接受率为80%。移植到裸（无胸腺）鼠后观察到最高接受率（100%）。在形态学上，两个动物组中的移植肿瘤相似，且与原发肿瘤相同。在两种动物模型中均未见到转移。用环孢素A处理的NMRI小鼠出现白细胞浸润到移植肿瘤中。正常小鼠体内人类肿瘤的生长速率取决于环孢素A的剂量，且在裸鼠中最高。通过流式细胞术判断，所有组中移植人类肿瘤的增殖率相当相似。
