Huland H, Otto U, von Paleske A
J Urol. 1985 Sep;134(3):601-6. doi: 10.1016/s0022-5347(17)47310-1.
Transitional and squamous-cell carcinomas of the bladder that were transplanted and successfully retransplanted in further passages to NMRI nu/nu mice were used to test the efficacy of chemotherapy. Mitomycin and bleomycin consistently retarded tumor growth; results with platinex and methotrexate were variable. Combination therapy was not much better than single-drug therapy. Substances that proved effective in the mouse model produced some response in the corresponding patients in a series of patients on specific chemotherapy. In a previous study we have shown that tumor growth of transplanted human bladder carcinoma accelerates, unlike transplanted renal cell carcinoma when successfully subpassaged, resulting in a uniformly fast growing rate similar in all transplanted tumors including those which initially started with slow growing rates. Most importantly, however, tests in a given tumor conducted on a slow-growing early passage and on a fast-growing late passage produced different results. We concluded that this finding might explain the clinical observation that tumor remission due to chemotherapy in patients with metastatic bladder carcinoma does not last very long and seldom prolongs survival. It is assumed--it is not proved--that substances that proved effective in fast growing passages are probably likely to yield greater prolongation of life than those effective in slow-growing passages.
将膀胱移行细胞癌和鳞状细胞癌移植到NMRI裸鼠体内，并在后续传代中成功再次移植，以此来测试化疗的疗效。丝裂霉素和博来霉素持续抑制肿瘤生长；顺铂和甲氨蝶呤的效果则各不相同。联合治疗并不比单药治疗好多少。在小鼠模型中被证明有效的物质，在一系列接受特定化疗的患者中，也使相应患者产生了一些反应。在先前的一项研究中，我们已经表明，与成功传代的移植肾细胞癌不同，移植的人类膀胱癌肿瘤生长会加速，导致所有移植肿瘤的生长速度均匀加快，包括那些最初生长速度较慢的肿瘤。然而，最重要的是，在给定肿瘤的早期生长缓慢传代和晚期生长快速传代上进行的测试产生了不同的结果。我们得出结论，这一发现可能解释了临床观察结果，即转移性膀胱癌患者化疗引起的肿瘤缓解持续时间不长，很少能延长生存期。据推测（未经证实），在快速生长传代中被证明有效的物质可能比在缓慢生长传代中有效的物质更能延长生命。
