The Nethersole School of Nursing, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong.
Department of Exercise Physiology, Sport Science School, Beijing Sport University, Beijing, China.
Climacteric. 2022 Dec;25(6):552-561. doi: 10.1080/13697137.2022.2097865. Epub 2022 Jul 29.
The frequency and severity of menopausal vasomotor symptoms negatively impact quality of life. This systematic review evaluates the potential of exercise to relieve the subjective frequency and severity of vasomotor symptoms. We searched four databases to identify randomized controlled trials (RCTs) that evaluated the effect of structured exercise (e.g. aerobic training) on the severity and/or frequency of vasomotor symptoms in menopausal women. Two reviewers independently screened records for eligibility, extracted data and assessed risks of bias and evidence certainty using the Cochrane tool and Grading of Recommendations Assessment, Development and Evaluation (GRADE). When suitable, data were pooled using random-effect meta-analyses. We appraised 21 RCTs involving 2884 participants. Compared to no-treatment control, exercise significantly improved severity of vasomotor symptoms (10 studies, standardized mean difference [SMD] = 0.25; 95% confidence interval [CI]: 0.04 to 0.47, = 0.02, very low certainty of evidence); the effect size was attenuated when studies with a high risk of bias were excluded (SMD = 0.11, 95% CI: -0.03 to 0.26, = 0.13). No significant changes in vasomotor frequency were found between exercise and control (SMD = 0.14, 95% CI: -0.03 to 0.31, = 0.12, high certainty of evidence). In conclusion, exercise might improve vasomotor symptom severity. Future rigorous RCTs addressing the limitations of current review are warranted to explore the optimal exercise prescription principles to target the severity of vasomotor symptoms.
绝经期血管舒缩症状的频率和严重程度会对生活质量产生负面影响。本系统评价评估了运动缓解血管舒缩症状主观频率和严重程度的潜力。我们检索了四个数据库，以确定评估结构性运动（如有氧运动）对绝经后妇女血管舒缩症状严重程度和/或频率影响的随机对照试验（RCT）。两名评审员独立筛选记录以确定其合格性，提取数据，并使用 Cochrane 工具和推荐评估、制定与评价（GRADE）评估偏倚风险和证据确定性。在适当的情况下，使用随机效应荟萃分析对数据进行汇总。我们评价了 21 项 RCT，涉及 2884 名参与者。与不治疗对照相比，运动显著改善了血管舒缩症状的严重程度（10 项研究，标准化均数差 [SMD] = 0.25；95%置信区间 [CI]：0.04 至 0.47， = 0.02，证据确定性极低）；当排除高偏倚风险的研究时，效应大小减弱（SMD = 0.11，95% CI：-0.03 至 0.26， = 0.13）。运动和对照组之间血管舒缩频率没有显著变化（SMD = 0.14，95% CI：-0.03 至 0.31， = 0.12，证据确定性高）。总之，运动可能改善血管舒缩症状的严重程度。未来需要进行严格的 RCT，以解决当前综述的局限性，探索针对血管舒缩症状严重程度的最佳运动处方原则。
