Department of Oral Pathology, Microbiology, and Forensic Odontology, Dental Institute, RIMS, Ranchi, India.
Department of Anatomy, RIMS, Ranchi, India.
Head Neck Pathol. 2022 Dec;16(4):1185-1194. doi: 10.1007/s12105-022-01474-1. Epub 2022 Jul 29.
Oral Squamous Cell Carcinoma (OSCC), a major debilitating illness demands focus in recent times due to a constant upsurge in cases and poor prognostic implications. An urgent mandate upon finding evidence of relevant prognostic markers is the need of the hour. This systematic review and meta-analysis, therefore, elect an objective assessment of Lymphatic Vessel Density (LVD) as a pertinent parameter governing OSCC prognosis.
The study protocol was registered at the International Prospective Register Of Systematic Reviews (PROSPERO). Databases were searched using the MeSH keywords for all study types following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. The exposure under consideration was the evaluation of LVD in patients of OSCC. The outcome was measured as pooled Hazard/Odd's/Risk ratios in survived versus non-survived OSCC population. The risk of bias assessment was performed using the QUIPS tool. Heterogeneity was assessed by Chi-square and I statistics whereas publication bias was investigated using Egger's test of significance. All the statistical analysis was conducted using STATA version 13.0.
The initial search of 226 records were screened and filtered through the inclusion and exclusion criteria to achieve an outcome of 15 studies for qualitative synthesis out of which seven studies were eligible for meta-analysis. Pooled Hazard of enhanced Lymphatic Vessel Density was not found to be statistically significant (HR = 1.98, p = 0.553); contrary to the pooled Odd's/Risk for patient survival which was statistically significant (RR = 1.33, p = 0.046). The I test of heterogeneity was also significant (58.8%, p = 0.046).
This meta-analysis helps to generate pathfinding evidence for a noteworthy role of Lymphatic Vessel Density evaluation in suggesting OSCC prognosis.
口腔鳞状细胞癌（OSCC）是一种主要的使人虚弱的疾病，由于病例不断增加和预后不良的影响，最近受到了关注。当发现相关预后标志物的证据时，迫切需要进行客观评估。因此，本系统评价和荟萃分析选择评估淋巴管密度（LVD）作为预测 OSCC 预后的相关参数。
该研究方案在国际前瞻性系统评价注册库（PROSPERO）中进行了注册。根据系统评价和荟萃分析的首选报告项目（PRISMA）指南，使用 MeSH 关键词搜索了所有研究类型的数据库。考虑的暴露因素是评估 OSCC 患者的 LVD。结局是在 OSCC 存活与非存活人群中测量的汇总风险比/优势比/风险比。使用 QUIPS 工具进行偏倚风险评估。使用 Chi-square 和 I 统计量评估异质性，使用 Egger 检验评估发表偏倚。所有统计分析均使用 STATA 版本 13.0 进行。
最初搜索了 226 条记录，通过纳入和排除标准进行筛选和过滤，得出 15 项研究进行定性综合分析，其中 7 项研究符合荟萃分析的条件。增强的淋巴管密度的汇总风险没有显示出统计学意义（HR=1.98，p=0.553）；相反，患者生存的汇总优势/风险比具有统计学意义（RR=1.33，p=0.046）。异质性 I 检验也具有统计学意义（58.8%，p=0.046）。
这项荟萃分析有助于为淋巴管密度评估在提示 OSCC 预后方面的重要作用提供开创性的证据。
