Department of Medical Laboratory Sciences, College of Health Sciences/Research Institute of Medical and Health Sciences (RIMHS), University of Sharjah, Sharjah, United Arab Emirates.
Biochemistry Department, Faculty of Science, Ain Shams University, Cairo, Egypt.
Diabetes Res Clin Pract. 2022 Aug;190:110024. doi: 10.1016/j.diabres.2022.110024. Epub 2022 Jul 26.
Haptoglobin (Hp) is a multifaceted marker of inflammation, and mediates the interplay between obesity, inflammation, and cardiometabolic dysfunction. However, the role of the Hp phenotype in modulating intermittent fasting (IF)-induced cardiometabolic changes remains to be elucidated.
Hp phenotype was determined for the study subjects. Cardiometabolic markers were assessed before and at the end of four consecutive weeks, dawn to sunset IF.
A total of 114 subjects (75 males and 39 females, 38.7 ± 11.7 years, body mass index (BMI) of 30.41 ± 5.09 kg/m) were recruited. Hp2-2 (n = 55, 48.2 %) and Hp2-1 (n = 53, 46.5 %) were the predominant phenotypes. Significant reductions were observed in serum Hp, IL-6, TNF-α, triglycerides (TG), total cholesterol (TC), LDL, BMI, and fat mass (FM), while a significant elevation was observed in serum CD163, HDL, and IL-10 at the end of the IF month for the whole population. Based on the Hp polymorphism, significant decreases in Hp, BMI, FM, TG, LDL, and TNF-α, with significant increases in HDL and CD163 levels were observed among subjects with Hp2-2 and Hp2-1 phenotypes. A more pronounced reduction in FM was reported in subjects with Hp2-2 in comparison with Hp2-1.
Hp gene polymorphism modulates IF-induced changes in cardiometabolic markers.
ISRCTN18205186; https://trialsearch.who.int/?TrialID=ISRCTN18205186.
触珠蛋白（Hp）是一种多方面的炎症标志物，介导肥胖、炎症和心脏代谢功能障碍之间的相互作用。然而，Hp 表型在调节间歇性禁食（IF）引起的心脏代谢变化中的作用仍有待阐明。
确定研究对象的 Hp 表型。在连续四周的 IF 期间，从黎明到日落，评估心脏代谢标志物。
共招募了 114 名受试者（75 名男性和 39 名女性，38.7±11.7 岁，体重指数（BMI）为 30.41±5.09kg/m）。Hp2-2（n=55，48.2%）和 Hp2-1（n=53，46.5%）是主要表型。整个人群在 IF 月结束时，血清 Hp、IL-6、TNF-α、甘油三酯（TG）、总胆固醇（TC）、LDL、BMI 和脂肪量（FM）显著降低，而血清 CD163、HDL 和 IL-10 显著升高。根据 Hp 多态性，在 Hp2-2 和 Hp2-1 表型的受试者中，观察到 Hp、BMI、FM、TG、LDL 和 TNF-α显著降低，而 HDL 和 CD163 水平显著升高。与 Hp2-1 相比，Hp2-2 受试者的 FM 降低更为明显。
Hp 基因多态性调节 IF 引起的心脏代谢标志物变化。
ISRCTN18205186；https://trialsearch.who.int/?TrialID=ISRCTN18205186。
