Schlafly Emily D, Marshall François A, Merricks Edward M, Eden Uri T, Cash Sydney S, Schevon Catherine A, Kramer Mark A
Graduate Program in Neuroscience, Boston University, Boston, Massachusetts 02215.
Department of Mathematics and Statistics & Center for Systems Neuroscience, Boston University, Boston, Massachusetts 02215.
J Neurosci. 2022 Sep 7;42(36):6966-6982. doi: 10.1523/JNEUROSCI.0338-22.2022.
During human seizures, organized waves of voltage activity rapidly sweep across the cortex. Two contradictory theories describe the source of these fast traveling waves: either a slowly advancing narrow region of multiunit activity (an ictal wavefront) or a fixed cortical location. Limited observations and different analyses prevent resolution of these incompatible theories. Here we address this disagreement by combining the methods and microelectrode array recordings ( = 11 patients, 2 females, = 31 seizures) from previous human studies to analyze the traveling wave source. We find, inconsistent with both existing theories, a transient relationship between the ictal wavefront and traveling waves, and multiple stable directions of traveling waves in many seizures. Using a computational model that combines elements of both existing theories, we show that interactions between an ictal wavefront and fixed source reproduce the traveling wave dynamics observed We conclude that combining both existing theories can generate the diversity of ictal traveling waves. The source of voltage discharges that propagate across cortex during human seizures remains unknown. Two candidate theories exist, each proposing a different discharge source. Support for each theory consists of observations from a small number of human subject recordings, analyzed with separately developed methods. How the different, limited data and different analysis methods impact the evidence for each theory is unclear. To resolve these differences, we combine the unique, human microelectrode array recordings collected separately for each theory and analyze these combined data with a unified approach. We show that neither existing theory adequately describes the data. We then propose a new theory that unifies existing proposals and successfully reproduces the voltage discharge dynamics observed .
在人类癫痫发作期间，有组织的电压活动波迅速扫过皮层。有两种相互矛盾的理论描述了这些快速传播波的来源：要么是多单位活动缓慢推进的狭窄区域（发作波前峰），要么是固定的皮层位置。有限的观察和不同的分析方法使得这两种不相容的理论无法得到解决。在这里，我们通过结合先前人类研究中的方法和微电极阵列记录（11名患者，2名女性，31次癫痫发作）来分析传播波的来源，从而解决这一争议。我们发现，与现有两种理论均不一致的是，发作波前峰与传播波之间存在短暂关系，并且在许多癫痫发作中传播波具有多个稳定方向。使用一个结合了现有两种理论要素的计算模型，我们表明发作波前峰与固定源之间的相互作用再现了所观察到的传播波动态。我们得出结论，将现有两种理论结合起来可以产生发作期传播波的多样性。在人类癫痫发作期间，在皮层中传播的电压放电源仍然未知。存在两种候选理论，每种理论都提出了不同的放电源。对每种理论的支持都来自于少数人类受试者记录的观察结果，并采用了分别开发的方法进行分析。目前尚不清楚不同的有限数据和不同的分析方法如何影响每种理论的证据。为了解决这些差异，我们将为每种理论分别收集的独特的人类微电极阵列记录结合起来，并采用统一的方法分析这些合并后的数据。我们表明，现有两种理论都不能充分描述这些数据。然后，我们提出了一种新理论，该理论统一了现有提议，并成功再现了所观察到的电压放电动态。
