[一种抑制造血细胞的因子对免疫应答发育的影响]
[Effect of a factor inhibiting hematopoietic cells on the development of the immune response].
作者信息
Kaulen D R, Golovanova T A, Ignat'eva O Iu, Mysiakin E B
出版信息
Biull Eksp Biol Med. 1981 May;91(5):630-2.
PMID:6973378
Abstract
Thymus cells from syngeneic donors treated in vitro with antilymphocyte globulin release into the medium a soluble hemopoietic stem cell inhibitory factor (SCIF). It has been found that SCIF inhibits the immune response to sheep red blood cells in the adoptive immunity system. Primarily affected by SCIF are the mature progenitors of B cells whose ability cooperate with T lymphocytes seems to be impaired. The role of lymphokines in the induction of the immune response is discussed.
摘要
用抗淋巴细胞球蛋白体外处理的同基因供体的胸腺细胞会向培养基中释放一种可溶性造血干细胞抑制因子（SCIF）。已发现SCIF在过继免疫系统中抑制对绵羊红细胞的免疫反应。主要受SCIF影响的是B细胞的成熟祖细胞，其与T淋巴细胞协作的能力似乎受损。文中讨论了淋巴因子在免疫反应诱导中的作用。
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