Shulan (Hangzhou) Hospital Affiliated to Zhejiang, Shuren University Shulan International Medical College, Hangzhou, China.
Sci Rep. 2022 Jul 29;12(1):13073. doi: 10.1038/s41598-022-17417-3.
Gut microbiome has been shown to play a role in the development of obesity in recent studies. Most of these studies on obesity were based on the BMI classification criteria, which doesn't distinguish Visceral adipose tissue (VAT) from subcutaneous adipose tissue (SAT). Some studies showed that VAT has a higher risk of inducing metabolic diseases than SAT. This study focused on the visceral obesity defined by increased visceral fat area. The present study was designed to investigate the association of visceral obesity with gut predominant microbiota and metabolic status. This study included 372 healthy individuals from medical examination center in Shulan Hangzhou Hospital. Quantitative polymerase chain reaction (q-PCR) technique was used to detect ten kinds of gut predominant bacteria in fresh feces. Visceral fat area (VFA) was measured by the bioimpedance analyzer (INBODY720, Korea). The abundance of Bifidobacterium significantly decreased in the visceral obesity group. Compared with the lean group, Visceral obesity group had significantly higher levels of LDL, TG, FBG, serum uric acid (SUA) and lower levels of HDL. SUA was an independent impact factor for Bifidobacterium. SUA was negatively correlated with Bifidobacterium and positively correlated with VFA. In the mediation analysis, SUA showed significant mediation effect. SUA may be a mediating factor between decreased Bifidobacterium and increased VAT.
近年来的研究表明，肠道微生物群在肥胖的发展中起作用。大多数关于肥胖的这些研究都是基于 BMI 分类标准，该标准不能区分内脏脂肪组织（VAT）和皮下脂肪组织（SAT）。一些研究表明，VAT 比 SAT 更有引发代谢疾病的风险。本研究侧重于由内脏脂肪增加定义的内脏肥胖。本研究旨在探讨内脏肥胖与肠道优势菌群和代谢状态的关系。该研究纳入了 372 名来自杭州市树兰医院体检中心的健康个体。使用定量聚合酶链反应（q-PCR）技术检测新鲜粪便中的十种肠道优势细菌。使用生物电阻抗分析仪（INBODY720，韩国）测量内脏脂肪面积（VFA）。双歧杆菌的丰度在内脏肥胖组中显著降低。与瘦组相比，内脏肥胖组的 LDL、TG、FBG、血清尿酸（SUA）水平显著升高，HDL 水平显著降低。SUA 是双歧杆菌的独立影响因素。SUA 与双歧杆菌呈负相关，与 VFA 呈正相关。在中介分析中，SUA 显示出显著的中介效应。SUA 可能是双歧杆菌减少和 VAT 增加之间的中介因素。
