Cassiano Daniel P, Espósito Ana Cláudia C, da Silva Carolina N, Lima Paula B, Dias Joana A F, Hassun Karime, Miot Luciane D B, Miot Hélio A, Bagatin Ediléia
Departamento de Dermatologia, UNIFESP, São Paulo, SP, Brazil.
Departamento de Dermatologia e Radioterapia, FMB-Unesp, Campus de Rubião Jr., Botucatu, SP, Brazil.
Dermatol Ther (Heidelb). 2022 Sep;12(9):1989-2012. doi: 10.1007/s13555-022-00780-4. Epub 2022 Jul 29.
Melasma is a prevalent chronic relapsing pigmentary disorder that affects photoexposed areas, especially in women of childbearing age. Although there is currently no curative treatment available for melasma, this manuscript critically reviews the knowledge regarding photoprotection, topical and oral therapies, and procedures such as peelings, laser, and microneedling that represent the main strategies for control and prevention of this disease. As the pathogenesis of melasma is not entirely understood, there are prospects for the development of new therapeutic strategies that might act on the pathways that promote sustained pigmentation rather than merely decreasing melanin synthesis and removing melanin from the epidermis.
黄褐斑是一种常见的慢性复发性色素沉着紊乱疾病，影响暴露于阳光下的部位，尤其是育龄女性。尽管目前尚无治愈黄褐斑的疗法，但本文批判性地综述了有关光防护、局部和口服疗法以及诸如化学剥脱、激光和微针治疗等程序的知识，这些代表了控制和预防该疾病的主要策略。由于黄褐斑的发病机制尚未完全明确，有可能开发出新的治疗策略，作用于促进持续性色素沉着的途径，而不仅仅是减少黑色素合成和从表皮去除黑色素。
