微针联合外用维生素C治疗黄褐斑的疗效
Efficacy of microneedling with topical vitamin C in the treatment of melasma.
作者信息
Ismail Esraa Salah Ali, Patsatsi Aikaterini, Abd El-Maged Wafaa Mohammed, Nada Essam El-Din Abd El-Aziz
机构信息
Faculty of Medicine, Department of Dermatology, Sohag University, Sohag University Hospital, Sohag, Egypt.
Faculty of Medicine, 2nd Department of Dermatology, Aristotle University, Papageorgiou General Hospital, Thessaloniki, Greece.
出版信息
J Cosmet Dermatol. 2019 Oct;18(5):1342-1347. doi: 10.1111/jocd.12878. Epub 2019 Feb 15.
BACKGROUND
Despite the wide therapeutic options available for the treatment of melasma, including many active topical medications, technologies with lights and peelings, clinical control of this disorder is extremely challenging.
OBJECTIVES
To evaluate the effect of microneedling with topical vitamin C in the treatment of melasma.
METHODS
Thirty female patients with melasma received six sessions of microneedling with addition of topical vitamin C every two weeks. At each session, photos were taken and Melasma Area and Severity Index (MASI) score was calculated to assess the clinical improvement.
RESULTS
Mean age of the eligible patients was 33.2 ± 5.77 years. About 50% of cases were of Fitzpatrick skin type III. All patients showed improvement at the end of the sessions. Mean MASI score in the first session was 8.61 ± 4.45 and there was a gradual decline in its value till it reached a mean of 5.75 ± 4.16 in the last session (P < 0.0001).
CONCLUSION
Microneedling with topical vitamin C is an effective and safe treatment option for epidermal melasma especially in Fitzpatrick skin phototypes I-III.
背景
尽管治疗黄褐斑有多种广泛的治疗选择，包括许多有效的外用药物、光疗技术和剥脱术，但对这种疾病的临床控制极具挑战性。
目的
评估微针联合外用维生素C治疗黄褐斑的效果。
方法
30例黄褐斑女性患者每两周接受6次微针治疗，并添加外用维生素C。每次治疗时拍照，并计算黄褐斑面积和严重程度指数（MASI）评分以评估临床改善情况。
结果
符合条件的患者平均年龄为33.2±5.77岁。约50%的病例为Fitzpatrick皮肤III型。所有患者在治疗结束时均有改善。第一次治疗时的平均MASI评分为8.61±4.45，其值逐渐下降，直至最后一次治疗时平均降至5.75±4.16（P<0.0001）。
结论
微针联合外用维生素C是治疗表皮型黄褐斑的一种有效且安全的治疗选择，尤其适用于Fitzpatrick皮肤I-III型。
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