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[膀胱移行细胞肿瘤中的凝集素受体]

[Lectin receptors in transitional cell tumors of the bladder].

作者信息

Dmitruk I M, Zerbino D D, Lutsik A D

出版信息

Vopr Onkol. 1987;33(4):60-5.

PMID:3590660
Abstract

Binding sites for lectins of peanuts, soya-beans and concanavalin A were identified in the tissues of normal human urinary bladder and its transitional cell tumors (31 patients) using the lectin-peroxidase technique. No binding sites for any of the lectins were found in normal urothelium. Receptors for peanut and soya-bean lectins were observed on the plasma membranes of 20% of tumor cells in transitional cell papillomas. A diffuse distribution of those lectins in tumor cell cytoplasm was interpreted as a tendency to malignant transformation of tumor. There were no concanavalin A receptors in tumor cells.

摘要

采用凝集素-过氧化物酶技术,在31例正常人膀胱组织及其移行细胞肿瘤中鉴定出花生、大豆凝集素和刀豆球蛋白A的结合位点。在正常尿路上皮中未发现任何凝集素的结合位点。在移行细胞乳头状瘤中,20%的肿瘤细胞质膜上观察到花生和大豆凝集素的受体。这些凝集素在肿瘤细胞胞质中的弥漫分布被解释为肿瘤恶变的倾向。肿瘤细胞中不存在刀豆球蛋白A受体。

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