Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.
Neurology Research Center, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Nutr J. 2022 Jul 30;21(1):50. doi: 10.1186/s12937-022-00802-z.
Literature suggests a relationship between estrogen levels and migraine headache pathogenesis. However, the effect of soy isoflavones on migraine characteristic remains unclear. This study aimed to investigate the effect of soy isoflavones on migraine characteristics and calcitonin gene-related peptide (CGRP) levels in women with migraine.
Eighty-three participants completed a randomized double-blind controlled trial, receiving 50 mg per day soy isoflavones or placebo supplementation for 8 weeks. Migraine severity, migraine days per month, frequency and duration of attacks, mental status, quality of life and serum CGRP levels were measured at baseline and the end of the intervention. Bivariate comparison and intention-to-treat (ITT) were used for analysis.
Soy isoflavones intake resulted in a significant decrease in mean frequency (-2.36 vs -0.43, P < 0.001), duration (-2.50 vs -0.02, P < 0.001) of migraine attacks and CGRP level (-12.18 ng/l vs -8.62, P = 0.002) in compared to placebo group. Also, a significant improvement was found in quality of life (16.76 vs 2.52, P < 0.001). Although, reduction in the migraine severity and mental status did not reach a statistically significant level (P > 0.05).
soy isoflavones supplementation may be considered as a complementary treatment for women with migraine to improve migraine characteristics and reduce the burden of disease.
文献表明雌激素水平与偏头痛发病机制之间存在关系。然而，大豆异黄酮对偏头痛特征的影响尚不清楚。本研究旨在探讨大豆异黄酮对偏头痛女性偏头痛特征和降钙素基因相关肽（CGRP）水平的影响。
83 名参与者完成了一项随机双盲对照试验，每天接受 50 毫克大豆异黄酮或安慰剂补充剂，持续 8 周。在基线和干预结束时测量偏头痛严重程度、每月偏头痛天数、发作频率和持续时间、精神状态、生活质量和血清 CGRP 水平。使用双变量比较和意向治疗（ITT）进行分析。
与安慰剂组相比，大豆异黄酮摄入可显著降低偏头痛发作的平均频率（-2.36 对-0.43，P < 0.001）、持续时间（-2.50 对-0.02，P < 0.001）和 CGRP 水平（-12.18 ng/l 对-8.62，P = 0.002）。此外，生活质量也得到了显著改善（16.76 对 2.52，P < 0.001）。尽管偏头痛严重程度和精神状态的改善没有达到统计学意义水平（P > 0.05）。
大豆异黄酮补充剂可被视为偏头痛女性的一种辅助治疗方法，可改善偏头痛特征并减轻疾病负担。
