[Effect of different supplies of vitamin K on the biotransformation of amidopyrine and benzoic acid in the rat].

Group I rats were given orally syncumar (1.5 mg/kg/day) during 5 days to induce K-avitaminosis. Group II and III animals received vikasol, a synthetic analogue of vitamin K (3 and 30 mg/kg/day, respectively), during 6 days. Delayed biotransformation of amidopyrine was recorded in the animals with vitamin K deficiency. The total 4-aminoantipyrine excretion was reduced due to a steady decrease in the excretion of both free form of this substance and its acetylated metabolite. Delayed conversion of benzoic acid into hippuric acid and benzoyl glucuronides was noted in rats with K-avitaminosis. Vikasol administration stimulated biotransformation of amidopyrine and benzoic acid, the low doses of vikasol (3 mg/kg) being more effective as compared to the high doses (30 mg/kg).