Associação Brasileira de Abordagens Neurofuncionais (ABDAN), Rio de Janeiro, Rio de Janeiro, Brazil.
Instituto de Pesquisa Professor Joaquim Amorim Neto (IPESQ), Campina Grande, Paraíba, Brazil.
J Paediatr Child Health. 2022 Nov;58(11):2008-2015. doi: 10.1111/jpc.16139. Epub 2022 Jul 30.
To evaluate the effects of neurodevelopmental treatment (NDT) in children with congenital Zika syndrome (CZS).
This prospective, interventional cohort study involved children with CZS undergoing follow-up at a specialist centre in northeastern Brazil. The duration of the proposed NDT protocol was 1 year, with 45-min sessions delivered one to five times weekly. Motor function, weight, height, head circumference and the incidence of comorbidities were evaluated in children before protocol initiation and then at 3, 6 and 12 months of treatment.
Thirty children were evaluated (age mean 30.1 ± 3 months). Motor function improved from baseline to 6 months (P = 0.001). No difference in weight and head circumference z-score (P = 0.51 and P = 0.29, respectively), but an increase in height z-score (P < 0.001) was observed over the evaluation period. There was a reduction in the incidence of upper respiratory tract infections, pneumonia and urinary tract infections over the follow-up period.
NDT proved to be a viable treatment approach that can improve motor function and reduce the incidence of comorbidities in children with CZS, while having no harmful effects on their growth.
评估神经发育治疗（NDT）对先天性寨卡综合征（CZS）患儿的疗效。
这是一项前瞻性、干预性队列研究，纳入了在巴西东北部一家专科中心接受随访的 CZS 患儿。拟议的 NDT 方案持续 1 年，每周 1-5 次，每次 45 分钟。在方案开始前和治疗后 3、6 和 12 个月，评估患儿的运动功能、体重、身高、头围和合并症的发生率。
共 30 例患儿接受了评估（平均年龄 30.1±3 个月）。运动功能从基线到 6 个月时得到改善（P=0.001）。体重和头围 z 评分无差异（P=0.51 和 P=0.29），但身高 z 评分在评估期间有所增加（P<0.001）。在随访期间，上呼吸道感染、肺炎和尿路感染的发生率有所降低。
NDT 是一种可行的治疗方法，可改善 CZS 患儿的运动功能，降低合并症的发生率，同时对其生长无不良影响。
