National Institute of Women, Children and Adolescents' Health Fernandes Figueira, Oswaldo Cruz Foundation, Rio de Janeiro 22250-020, Brazil.
David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
Viruses. 2022 Apr 23;14(5):876. doi: 10.3390/v14050876.
Little is known about the impact of congenital Zika virus (ZIKV) exposure on growth in the first years of life. In this prospective cohort study,201 ZIKV antenatally-exposed children were followed at a tertiary referral center in Rio de Janeiro, Brazil. Eighty-seven were classified as congenital Zika syndrome (CZS) patients and 114 as not congenital Zika syndrome (NCZS); growth parameters were described and compared between groups and with WHO standard growth curves. Thirty-four (39%) newborns with CZS and seven (6%) NCZS were small for gestational age (p < 0.001). NCZS mean weight measures ranged from −0.45 ± 0.1 to 0.27 ± 0.2 standard deviations (SD) from the WHO growth curve median during follow-up, versus −1.84 ± 0.2 to −2.15 ± 0.2 SD for the CZS group (p < 0.001). Length mean z-scores varied from −0.3 ± 0.1 at 1 month to 0.17 ± 0.2 SD between 31 and 36 months in the NCZS group, versus −2.3 ± 0.3 to −2.0 ± 0.17 SD in the CZS group (p < 0.001). Weight/height (W/H) and BMI z-scores reached -1.45 ± 0.2 SD in CZS patients between 31 and 36 months, versus 0.23 ± 0.2 SD in the NCZS group (p < 0.01). Between 25 and 36 months of age, more than 50% of the 70 evaluated CZS children were below weight and height limits; 36 (37.1%) were below the W/H cut-off. Gastrostomy was performed in 23 (26%) children with CZS. During the first three years of life, CZS patients had severe and early growth deficits, while growth of NCZS children was normal by WHO standards.
关于先天性寨卡病毒（ZIKV）暴露对生命最初几年生长的影响知之甚少。在这项前瞻性队列研究中，201 名 ZIKV 产前暴露的儿童在巴西里约热内卢的一家三级转诊中心接受随访。87 名被归类为先天性寨卡综合征（CZS）患者，114 名归类为非先天性寨卡综合征（NCZS）；描述了生长参数，并比较了两组之间以及与世界卫生组织（WHO）标准生长曲线之间的差异。34 名（39%）患有 CZS 的新生儿和 7 名（6%）NCZS 的新生儿为小于胎龄儿（p<0.001）。NCZS 平均体重测量值在随访期间从 WHO 生长曲线中位数的-0.45±0.1 到-0.27±0.2 标准差（SD）不等，而 CZS 组的平均值为-1.84±0.2 到-2.15±0.2 SD（p<0.001）。长度平均 z 评分在 NCZS 组中从 1 个月时的-0.3±0.1 到 31 至 36 个月时的 0.17±0.2 SD 不等，而 CZS 组中的值为-2.3±0.3 到-2.0±0.17 SD（p<0.001）。体重/身高（W/H）和 BMI z 评分在 CZS 患者中在 31 至 36 个月之间达到-1.45±0.2 SD，而在 NCZS 组中达到 0.23±0.2 SD（p<0.01）。在 25 至 36 个月龄时，70 名评估的 CZS 儿童中有超过 50%的体重和身高低于限值；36 名（37.1%）低于 W/H 截止值。23 名 CZS 儿童进行了胃造口术。在生命的头三年中，CZS 患者的生长严重且早期出现缺陷，而 NCZS 儿童的生长则符合 WHO 标准。
