Department of Urology, Hospital Universitario Ramón y Cajal, Madrid, Spain, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), University of Alcalá, Madrid, Spain.
Department of Urology, Hospital Universitario Ramón y Cajal, Madrid, Spain, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), University of Alcalá, Madrid, Spain.
Transplant Proc. 2022 Jul-Aug;54(6):1583-1588. doi: 10.1016/j.transproceed.2022.03.056. Epub 2022 Jul 28.
The main indication for kidney autotransplantation is ureteric disease, although it is also performed to treat renovascular diseases or neoplasms, such as complex intrasinusal kidney tumors or in patients with a solitary kidney. Only a few cases of kidney autotransplantation in the context of resection of complex retroperitoneal masses have been reported in the literature. CASE PRESENTATION: We report the case of a 26-year-old man with history of nonseminomatous germ cell tumor who had undergone a left radical orchiectomy 3 months earlier. Follow-up computed tomography revealed a residual retroperitoneal postchemotherapy mass involving the renal hilum. It was surgically removed via en bloc resection and bench ex vivo nephron-sparing surgery, and subsequently autotransplantation, thereby avoiding the necessity of nephrectomy and the resulting risk of chronic kidney disease. The pathology of the excised specimen demonstrated mixed germ cell tumor, composed of immature teratoma and yolk sac tumor, and confirmed tumor-free margins. CONCLUSIONS: This technique should be taken into account in selected patients as an alternative to radical nephrectomy when a retroperitoneal tumor is unresectable using standard surgical techniques or when a radical nephrectomy is considered, especially in patients with chronic kidney disease or solitary kidney, or in young patients who will potentially need nephrotoxic chemotherapy.
肾自体移植的主要适应证为输尿管疾病,尽管它也可用于治疗肾血管疾病或肿瘤,如复杂的鼻窦内肾肿瘤或孤立肾患者。文献中仅报道了少数几例在切除复杂腹膜后肿块的情况下进行肾自体移植的病例。
我们报告了 1 例 26 岁的非精原细胞瘤生殖细胞肿瘤患者的病例,该患者 3 个月前接受了左侧根治性睾丸切除术。随访 CT 显示残余腹膜后化疗后肿块累及肾门。通过整块切除和 bench 体外肾单位保留手术进行了手术切除,随后进行了自体移植,从而避免了肾切除术和由此导致的慢性肾脏病风险。切除标本的病理学显示混合性生殖细胞瘤,由未成熟畸胎瘤和卵黄囊瘤组成,并证实肿瘤无边缘。
当腹膜后肿瘤无法通过标准手术技术切除或考虑根治性肾切除术时,特别是对于患有慢性肾脏病或孤立肾的患者,或对于需要肾毒性化疗的年轻患者,该技术应作为根治性肾切除术的替代方案在选定的患者中考虑。