Jo Yeonggwon, Hwang Dong Gyu, Kim Myungji, Yong Uijung, Jang Jinah
School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea.
Department of Convergence IT Engineering, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea.
Trends Biotechnol. 2023 Jan;41(1):93-105. doi: 10.1016/j.tibtech.2022.07.001. Epub 2022 Jul 28.
Various external cues can guide cellular behavior and maturation during developmental processes. Recent studies on bioprinting-assisted tissue engineering have considered this a practical, versatile, and flexible way to provide external cues to developing engineered tissues. An ensemble of multiple external cues can improve the speed and capability of morphogenesis. In this review, we discuss how bioprinting and biomaterials provide multiple guidance to generate micro-sized building blocks with specific shapes and also highlight their applications in tissue assembly toward volumetric tissue and organ generation. Furthermore, we discuss our perspectives on the future translation of bioprinting technologies integrated with artificial intelligence (AI) and robot-assisted apparatus to promote automation, standardization, and clinical translation of bioprinted tissues.
在发育过程中，各种外部信号可以引导细胞行为和成熟。最近关于生物打印辅助组织工程的研究认为，这是一种为发育中的工程组织提供外部信号的实用、通用且灵活的方法。多种外部信号的组合可以提高形态发生的速度和能力。在这篇综述中，我们讨论了生物打印和生物材料如何提供多种引导以生成具有特定形状的微型构建块，并强调了它们在组织组装以实现体积组织和器官生成方面的应用。此外，我们还讨论了我们对生物打印技术与人工智能（AI）和机器人辅助设备相结合的未来转化的看法，以促进生物打印组织的自动化、标准化和临床转化。
