He Zheng, Starkuviene Vytaute, Keese Michael
BioQuant, Heidelberg University, Im Neuenheimer Feld 267, 69120 Heidelberg, Germany.
European Center of Angioscience (ECAS), Medical Faculty Mannheim, Heidelberg University, Ludolf-Krehl-Straße 13-17, 68167 Mannheim, Germany.
J Clin Med. 2025 Jan 21;14(3):660. doi: 10.3390/jcm14030660.
Mesenchymal stem cells (MSCs) are a family of multipotent stem cells that show self-renewal under proliferation, multilineage differentiation, immunomodulation, and trophic function. Thus, these cells, such as adipose tissue-derived mesenchymal stem cells (ADSCs), bone marrow-derived MSCs (BM-MSCs), and umbilical cord-derived mesenchymal stem cells (UC-MSCs), carry great promise for novel clinical treatment options. However, the challenges associated with the isolation of MSCs and the instability of their in vitro expansion remain significant barriers to their clinical application. The plasma membrane-spanning P-glycoprotein ATP-binding cassette subfamily B member 5 positive MSCs (ABCB5 MSCs) derived from human skin specimens offer a distinctive advantage over other MSCs. They can be easily extracted from the dermis and expanded. In culture, ABCB5 MSCs demonstrate robust innate homeostasis and a classic trilineage differentiation. Additionally, their ability to modulate the recipients' immune system highlights their potential for allogeneic applications in regenerative medicine. In this review, we primarily discuss the differentiation potential of ABCB5 MSCs and their perspectives in regenerative medicine.
间充质干细胞（MSCs）是一类多能干细胞，在增殖过程中表现出自我更新能力、多向分化能力、免疫调节能力和营养功能。因此，这些细胞，如脂肪组织来源的间充质干细胞（ADSCs）、骨髓来源的间充质干细胞（BM-MSCs）和脐带来源的间充质干细胞（UC-MSCs），为新型临床治疗方案带来了巨大希望。然而，与间充质干细胞分离相关的挑战以及其体外扩增的不稳定性仍然是其临床应用的重大障碍。源自人类皮肤标本的跨质膜P-糖蛋白ATP结合盒亚家族B成员5阳性间充质干细胞（ABCB5 MSCs）相对于其他间充质干细胞具有独特优势。它们可以很容易地从真皮中提取并扩增。在培养过程中，ABCB5 MSCs表现出强大的固有稳态和经典的三系分化能力。此外，它们调节受体免疫系统的能力突出了其在再生医学中异体应用的潜力。在这篇综述中，我们主要讨论ABCB5 MSCs的分化潜能及其在再生医学中的前景。
