Wei Lai, Wang Zeyu, Jing Niancai, Lu Yi, Yang Jili, Xiao Hongyu, Guo Huanyu, Sun Shoukun, Li Mingjing, Zhao Daqing, Li Xiangyan, Qi Wenxiu, Zhang Yue
College of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, 130117, Jilin, China.
Department of Scientific Research, Changchun University of Chinese Medicine, Changchun, 130117, Jilin, China.
Chin Med. 2022 Jul 30;17(1):90. doi: 10.1186/s13020-022-00645-0.
Hepatocellular carcinoma (HCC, accounting for 90% of primary liver cancer) was the sixth most common cancer in the world and the third leading cause of cancer death in 2020. The number of new HCC patients in China accounted for nearly half of that in the world. HCC was of occult and complex onset, with poor prognosis. Clinically, at least 15% of patients with HCC had strong side effects of interventional therapy (IT) and have poor sensitivity to chemotherapy and targeted therapy. Traditional Chinese medicine (TCM), as a multi-target adjuvant therapy, had been shown to play an active anti-tumor role in many previous studies. This review systematically summarized the role of TCM combined with clinically commonly used drugs for the treatment of HCC (including mitomycin C, cyclophosphamide, doxorubicin, 5-fluorouracil, sorafenib, etc.) in the past basic research, and summarized the efficacy of TCM combined with surgery, IT and conventional therapy (CT) in clinical research. It was found that TCM, as an adjuvant treatment, played many roles in the treatment of HCC, including enhancing the tumor inhibition, reducing toxic and side effects, improving chemosensitivity and prolonging survival time of patients. This review summarized the advantages of integrated traditional Chinese and modern medicine in the treatment of HCC and provides a theoretical basis for clinical research.
肝细胞癌（HCC，占原发性肝癌的90%）是2020年全球第六大常见癌症，也是癌症死亡的第三大主要原因。中国新增HCC患者数量占全球近一半。HCC起病隐匿且复杂，预后较差。临床上，至少15%的HCC患者介入治疗（IT）副作用大，对化疗和靶向治疗敏感性差。中药（TCM）作为一种多靶点辅助治疗方法，在以往许多研究中已显示出积极的抗肿瘤作用。本综述系统总结了过去基础研究中中药联合临床常用药物（包括丝裂霉素C、环磷酰胺、阿霉素、5-氟尿嘧啶、索拉非尼等）治疗HCC的作用，并总结了临床研究中中药联合手术、IT及传统治疗（CT）的疗效。研究发现，中药作为辅助治疗，在HCC治疗中发挥着多种作用，包括增强肿瘤抑制作用、减轻毒副作用、提高化疗敏感性及延长患者生存时间。本综述总结了中西医结合治疗HCC的优势，为临床研究提供了理论依据。
