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Discovery of a drug to treat airway mucus hypersecretion.

作者信息

Dickey Burton F, Lai Ying, Frick Manfred, Brunger Axel T

机构信息

Department of Pulmonary Medicine, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

National Clinical Research Center for Geriatrics, West China Hospital, State Key Laboratory of Biotherapy and Collaborative Innovation Center of Biotherapy, Sichuan University, Chengdu, China.

出版信息

Clin Transl Med. 2022 Aug;12(8):e972. doi: 10.1002/ctm2.972.

DOI:10.1002/ctm2.972
PMID:35908252
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9339237/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a02c/9339237/ecf8b82a080a/CTM2-12-e972-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a02c/9339237/ecf8b82a080a/CTM2-12-e972-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a02c/9339237/ecf8b82a080a/CTM2-12-e972-g001.jpg

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本文引用的文献

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Screening of Hydrocarbon-Stapled Peptides for Inhibition of Calcium-Triggered Exocytosis.筛选用于抑制钙触发的胞吐作用的烃链稳定肽
Front Pharmacol. 2022 Jun 17;13:891041. doi: 10.3389/fphar.2022.891041. eCollection 2022.
2
Design of protein-binding proteins from the target structure alone.从目标结构设计蛋白质结合蛋白。
Nature. 2022 May;605(7910):551-560. doi: 10.1038/s41586-022-04654-9. Epub 2022 Mar 24.
3
Inhibition of calcium-triggered secretion by hydrocarbon-stapled peptides.烃 stapled 肽抑制钙触发的分泌。
Nature. 2022 Mar;603(7903):949-956. doi: 10.1038/s41586-022-04543-1. Epub 2022 Mar 23.
4
Autophagy of mucin granules contributes to resolution of airway mucous metaplasia.粘蛋白颗粒的自噬有助于气道粘液化生的消退。
Sci Rep. 2021 Jun 22;11(1):13037. doi: 10.1038/s41598-021-91932-7.
5
Mucus Plugs and Emphysema in the Pathophysiology of Airflow Obstruction and Hypoxemia in Smokers.黏液栓与肺气肿在吸烟人群气流阻塞与低氧血症发病机制中的作用
Am J Respir Crit Care Med. 2021 Apr 15;203(8):957-968. doi: 10.1164/rccm.202006-2248OC.
6
Muco-Obstructive Lung Diseases.黏液阻塞性肺部疾病
N Engl J Med. 2019 May 16;380(20):1941-1953. doi: 10.1056/NEJMra1813799.
7
Emerging Concepts and Therapies for Mucoobstructive Lung Disease.黏液阻塞性肺病的新概念和治疗方法。
Ann Am Thorac Soc. 2018 Nov;15(Suppl 3):S216-S226. doi: 10.1513/AnnalsATS.201806-368AW.
8
Airway Mucin Secretion.气道黏液分泌。
Ann Am Thorac Soc. 2018 Nov;15(Suppl 3):S164-S170. doi: 10.1513/AnnalsATS.201806-371AW.
9
Dawn of a New Era in the Diagnosis and Treatment of Airway Mucus Dysfunction.气道黏液功能障碍诊断与治疗新时代的曙光
Am J Respir Crit Care Med. 2019 Jan 15;199(2):133-134. doi: 10.1164/rccm.201808-1444ED.
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Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction.哮喘患者的黏液栓与嗜酸性粒细胞增多和气流阻塞有关。
J Clin Invest. 2018 Mar 1;128(3):997-1009. doi: 10.1172/JCI95693. Epub 2018 Feb 5.