Yoon Kim Dae, Kwon Lee Jae
College of Pharmacy, Chungbuk National University, Chungbuk 361-763, Republic of Korea.
Department of Biology Education, College of Education, Chungbuk National University, Cheongju 361-763, Republic of Korea.
Cell Immunol. 2022 Sep;379:104578. doi: 10.1016/j.cellimm.2022.104578. Epub 2022 Jul 18.
Diabetes mellitus (DM), also called diabetes, is a chronic metabolic disorder, with complications that include failure of immune responses, such as immune cell proliferation and activation. The current study investigated changes in natural killer (NK) cell activity under diabetic conditions. To demonstrate the influence of hyperglycemia on NK cell activity, type 1 and 2 diabetes models were constructed using C57/BL6 mice. NK cells isolated from mice with either type 1 or 2 diabetes showed lower cytotoxic activity against cancer cells than NK cells isolated from healthy control mice, and the longer the duration since induction of diabetes, the lower was the cytotoxic activity. Moreover, in the diabetic mouse models, fewer NK cells expressed activation markers, such as NKG2D and NKp46, compared to NK cells from control mice. Production of the apoptosis inducer, granzyme B, was also lower in NK cells from diabetic mice than control mice. These results demonstrate that high glucose conditions influence NK cell activity.
糖尿病（DM），也称为糖尿病，是一种慢性代谢紊乱疾病，其并发症包括免疫反应衰竭，如免疫细胞增殖和激活。本研究调查了糖尿病条件下自然杀伤（NK）细胞活性的变化。为了证明高血糖对NK细胞活性的影响，使用C57/BL6小鼠构建了1型和2型糖尿病模型。从1型或2型糖尿病小鼠中分离出的NK细胞对癌细胞的细胞毒性活性低于从健康对照小鼠中分离出的NK细胞，并且糖尿病诱导后的时间越长，细胞毒性活性越低。此外，在糖尿病小鼠模型中，与对照小鼠的NK细胞相比，表达激活标志物（如NKG2D和NKp46）的NK细胞较少。糖尿病小鼠的NK细胞中凋亡诱导剂颗粒酶B的产生也低于对照小鼠。这些结果表明高糖条件会影响NK细胞活性。
