Hacettepe University Faculty of Medicine, Department of Internal Medicine, Ankara, Turkey.
Hacettepe University Faculty of Medicine, Department of Internal Medicine, Ankara, Turkey.
Nutrition. 2022 Nov-Dec;103-104:111765. doi: 10.1016/j.nut.2022.111765. Epub 2022 Jun 11.
Oncology may be the most rapidly expanding field in medicine, with several innovative diagnostic and therapeutic procedures appearing daily. Advances in oncology have improved the survival rate for patients with cancer and promoting quality of life is now one of the goals in the care of these patients. Patients face a variety of disease- and treatment-related side effects, including anorexia, nausea, vomiting, recurring infections, and sleep difficulties. Cancer-related cognitive impairment (CRCI) is an overlooked clinical condition found in oncologic practice, particularly in patients with breast cancer. Although several potential mechanisms for CRCI have been hypothesized, to our knowledge, the exact mechanism is still unknown. Alterations in the tryptophan kynurenine pathway have been shown to impair cognitive skills in several mental illnesses. However, its possible function in CRCI has yet to be investigated. The aim of this was to examine the possible interactions between tryptophan catabolism and CRCI.
肿瘤学可能是医学领域发展最快的学科，每天都有几种创新的诊断和治疗方法出现。肿瘤学的进步提高了癌症患者的生存率，提高生活质量现在是这些患者护理的目标之一。患者面临着各种与疾病和治疗相关的副作用，包括厌食、恶心、呕吐、反复感染和睡眠困难。癌症相关认知障碍 (CRCI) 是肿瘤学实践中一种被忽视的临床情况，尤其是在乳腺癌患者中。尽管已经假设了 CRCI 的几种潜在机制，但据我们所知，确切的机制仍不清楚。色氨酸犬尿氨酸途径的改变已被证明会损害几种精神疾病患者的认知技能。然而，其在 CRCI 中的可能作用尚未得到研究。本研究旨在探讨色氨酸分解代谢与 CRCI 之间可能的相互作用。
