Department of Anesthesiology, Liuyang Maternal and Child Health Hospital, 410300 Liuyang, Hunan, China.
Department of Neonatology, Liuyang Maternal and Child Health Hospital, 410300 Liuyang, Hunan, China.
Actas Esp Psiquiatr. 2024 Oct;52(5):733-740. doi: 10.62641/aep.v52i5.1748.
Perinatal depression is a prevalent mental disorder among pregnant women, characterized by sleep disturbances, appetite changes, negative emotions, cognitive impairment, and suicidal or homicidal tendencies. These symptoms severely compromise personal well-being, disrupt family life, and burden society. Early detection and intervention are thus crucial. The tryptophan-kynurenine (TRP-KYN) pathway is central to the inflammatory hypothesis of depression and has gained significant attention in perinatal depression research. This pathway encompasses numerous metabolic enzymes and neuroactive metabolites that interact with other physiological systems, influencing neurotransmitter synthesis and neuronal development. Through these interactions, the TRP-KYN pathway exerts psychotropic effects. This article reviews the key metabolites and enzymes of the TRP-KYN pathway and examines its intersection with immune inflammation, hormones, and gut microbiota.
围产期抑郁症是孕妇中常见的精神障碍，其特征是睡眠障碍、食欲变化、负面情绪、认知障碍和自杀或杀人倾向。这些症状严重损害个人健康，扰乱家庭生活，给社会带来负担。因此，早期发现和干预至关重要。色氨酸-犬尿氨酸（TRP-KYN）途径是抑郁症炎症假说的核心，在围产期抑郁症研究中受到了广泛关注。该途径包含许多代谢酶和神经活性代谢物，与其他生理系统相互作用，影响神经递质的合成和神经元的发育。通过这些相互作用，TRP-KYN 途径发挥精神作用。本文综述了 TRP-KYN 途径的关键代谢物和酶，并研究了其与免疫炎症、激素和肠道微生物群的相互作用。
