细胞坏死通路在肿瘤发生中的作用。
Necroptosis pathways in tumorigenesis.
机构信息
Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA; Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Hangzhou 310006, China.
出版信息
Semin Cancer Biol. 2022 Nov;86(Pt 3):32-40. doi: 10.1016/j.semcancer.2022.07.007. Epub 2022 Jul 28.
Abstract
Necroptosis is a caspase-independent form of programmed cell death executed by the receptor interacting protein kinase 1 (RIPK1)-RIPK3-mixed lineage kinase domain-like protein (MLKL) signaling cascade, deregulation of which can cause various human diseases including cancer. Escape from programmed cell death is a hallmark of cancer, leading to uncontrolled growth and drug resistance. Therefore, it is crucial to further understand whether necroptosis plays a key role in therapeutic resistance. In this review, we summarize the recent findings of the link between necroptosis and cancer, and discuss that targeting necroptosis is a new strategy to overcome apoptosis resistance in tumor therapy.
摘要
细胞程序性坏死是一种由受体相互作用蛋白激酶 1（RIPK1）-RIPK3-混合谱系激酶结构域样蛋白（MLKL）信号级联反应执行的、不依赖半胱天冬酶的细胞程序性死亡形式，其失调可导致包括癌症在内的各种人类疾病。逃避细胞程序性死亡是癌症的一个标志，导致不受控制的生长和耐药性。因此，进一步了解细胞程序性坏死是否在治疗耐药性中起关键作用至关重要。在这篇综述中，我们总结了细胞程序性坏死与癌症之间联系的最新发现，并讨论了靶向细胞程序性坏死是克服肿瘤治疗中细胞凋亡耐药性的一种新策略。
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