Department of Internal Medicine, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.
Department of Internal Medicine, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.
J Equine Vet Sci. 2022 Nov;118:104088. doi: 10.1016/j.jevs.2022.104088. Epub 2022 Jul 28.
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), like phenylbutazone (PBZ), are prescribed to treat pain and inflammation in the equine. However, experimentally their use has been associated with the development of Equine Glandular Gastric Disease (EGGD). To evaluate the prophylactic effects of Glycyrrhiza glabra root extracts (GGRE) on EGGD induction following oral administration of PBZ, 12 donkeys were used. Animals were divided into three equal groups (A, B and C) in a randomized block design. A: placebo, B: PBZ (4.4 mg/kg PO q 12 h) and C: PBZ plus GGRE (17.6 mg/kg PO q 24h). Gastroscopy and blood sampling for CBC, biochemical tests and antioxidant status were performed days 0 and 7. All but 1 animal had no EGGD lesions on day 0, but on day 7, severe EGGD lesions were seen in group B animals (grade 1/4 (× 1), grade 2/4 (× 2), and grade 3/4 (× 1)). Only mild changes were seen in group C animals, the most severe lesions being grade 1/4 lesions in 2 animals. No change was observed in Group A. Hematology and serum antioxidant status did not change significantly in any group. In group B glucose decreased and ALT and ALP increased, while in group C only ALP increased. In conclusion, GGRE reduced the severity of EGGD caused by PBZ. Further, GGRE prevented PBZ induced hypoglycemia and might reduce the possible hepatic injury of PBZ.
非甾体抗炎药（NSAIDs），如苯丁唑酮（PBZ），被开给马治疗疼痛和炎症。然而，实验表明，它们的使用与马腺胃疾病（EGGD）的发展有关。为了评估甘草根提取物（GGRE）对 PBZ 口服后诱导 EGGD 的预防作用，使用了 12 匹驴。动物按随机区组设计分为三组（A、B 和 C）。A：安慰剂，B：PBZ（4.4mg/kg PO q12h），C：PBZ 加 GGRE（17.6mg/kg PO q24h）。第 0 天和第 7 天进行胃镜检查和全血细胞计数（CBC）、生化试验和抗氧化状态的血液取样。除 1 只动物外，所有动物在第 0 天均无 EGGD 病变，但在第 7 天，B 组动物出现严重的 EGGD 病变（1/4 级病变（×1），2/4 级病变（×2）和 3/4 级病变（×1））。C 组动物仅见轻度变化，最严重的病变为 2 只动物的 1/4 级病变。A 组无变化。B 组的血液学和血清抗氧化状态在任何组均无显著变化。B 组的血糖降低，ALT 和 ALP 升高，而 C 组仅 ALP 升高。总之，GGRE 减轻了 PBZ 引起的 EGGD 的严重程度。此外，GGRE 可预防 PBZ 引起的低血糖，并可能减轻 PBZ 引起的肝损伤。
