恶性疟非免疫患者的止血缺陷：无弥散性血管内凝血证据。
Haemostatic defect in non-immune patients with falciparum malaria: no evidence of diffuse intravascular coagulation.
作者信息
Vreeken J, Cremer-Goote T M
出版信息
Br Med J. 1978 Aug 19;2(6136):533-5. doi: 10.1136/bmj.2.6136.533.
Abstract
Nine non-immune patients with imported falciparum malaria were examined for signs of diffuse intravascular coagulation (DIC). Although all had thrombocytopenia initially and some later had a decline in plasma fibrinogen concentrations, DIC was never detected, even in severely affected patients with coma and kidney damage. None of the patients were given heparin and all recovered without residual symptoms. Heparin administration should probably be considered only when clear-cut DIC, which possibly never occurs in falciparum malaria, has been demonstrated.
摘要
对9例输入性恶性疟非免疫患者进行了弥漫性血管内凝血（DIC）体征检查。尽管所有患者最初均有血小板减少，部分患者后来血浆纤维蛋白原浓度下降，但即使是患有昏迷和肾损伤的重症患者，也从未检测到DIC。所有患者均未接受肝素治疗，且均康复，无残留症状。仅当已证实存在明确的DIC（恶性疟可能从未出现过这种情况）时，或许才应考虑给予肝素治疗。
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