Key Laboratory of Leather Chemistry and Engineering (Sichuan University), Ministry of Education, Chengdu 610065, China; Research Center of Biomedical Engineering, Sichuan University, Chengdu, Sichuan 610065, China.
Department of Pharmacy, West China Hospital, Sichuan University, Chengdu 610041, China.
Int J Biol Macromol. 2022 Sep 1;216:741-756. doi: 10.1016/j.ijbiomac.2022.07.199. Epub 2022 Jul 28.
Collagen is the most abundant protein in animals and one of the most important extracellular matrices that chronically plays an important role in biomaterials. However, the major concern about native collagen is the lack of its thermal stability and weak resistance to proteolytic degradation. Currently, a series of modification technologies have been explored for critical nature and stability enhancement in collagen matrix-based biomaterials, and prosperously large-scale progress has been achieved. The establishment of covalent bonds among collagen noumenon has been verified assuringly to have pregnant influences on its physicochemical properties and biological properties, enlightening to discuss the disparate modification technologies on specific effects on the multihierarchical structures and pivotal performances of collagen. In this review, various existing modification methods were classified from a new perspective, scilicet whether to introduce exogenous substances, to reveal the basic scientific theories of collagen modification. Understanding the role of modification technologies in the enhancement of collagen performance is crucial for developing novel collagen-based biomaterials. Moreover, the different modification effects caused by the interaction sites between the modifier and collagen, and the structure-activity relationship between the structure of the modifier and the properties of collagen were reviewed.
胶原蛋白是动物中最丰富的蛋白质之一，也是最重要的细胞外基质之一，它在生物材料中起着重要的作用。然而，天然胶原蛋白的主要问题是缺乏热稳定性和对蛋白水解降解的弱抵抗力。目前，已经探索了一系列的改性技术来提高胶原蛋白基质生物材料的关键性质和稳定性，并取得了很大的进展。胶原蛋白本体之间形成共价键已经被证实对其物理化学性质和生物性质有重要影响，这启发我们讨论不同的改性技术对胶原蛋白多层次结构和关键性能的具体影响。在这篇综述中，我们从一个新的角度对各种现有的改性方法进行了分类，即是否引入外源性物质，以揭示胶原蛋白改性的基本科学理论。了解改性技术在增强胶原蛋白性能方面的作用对于开发新型胶原蛋白基生物材料至关重要。此外，还综述了修饰剂与胶原蛋白之间的相互作用位点以及修饰剂的结构与胶原蛋白性质之间的结构-活性关系对不同改性效果的影响。
