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用于脊髓损伤修复的可植入3D打印支架的最新进展

Recent Advances in Implantable 3D-Printed Scaffolds for Repair of Spinal Cord Injury.

作者信息

Khaledian Salar, Mohammadi Ghobad, Abdoli Mohadese, Fatahian Arad, Fatahian Arya, Fatahian Reza

机构信息

Infectious Diseases Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Clinical Research Development Center, Taleghani and Imam Ali Hospitals, Kermanshah University of Medical Sciences, Kermanshah, Iran.

出版信息

Adv Pharm Bull. 2024 Jul;14(2):331-345. doi: 10.34172/apb.2024.032. Epub 2024 Mar 10.

DOI:10.34172/apb.2024.032
PMID:39206398
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11347741/
Abstract

Spinal cord injury (SCI) is an important factor in sensory and motor disorders that affects thousands of people every year. Currently, despite successes in basic science and clinical research, there are few effective methods in the treatment of chronic and acute spinal cord injuries. In the last decade, the use of 3D printed scaffolds in the treatment of SCI had satisfactory and promising results. By providing a microenvironment around the injury site and in combination with growth factors or cells, 3D printed scaffolds help in axon regeneration as well as neural recovery after SCI. Here, we provide an overview of tissue engineering, 3D printing scaffolds, the different polymers used and their characterization methods. This review highlights the recent encouraging applications of 3D printing scaffolds in developing the novel SCI therapy.

摘要

脊髓损伤（SCI）是导致感觉和运动障碍的一个重要因素，每年影响着成千上万的人。目前，尽管基础科学和临床研究取得了一些成果，但在治疗急慢性脊髓损伤方面有效的方法仍然很少。在过去十年中，3D打印支架在脊髓损伤治疗中的应用取得了令人满意且前景广阔的成果。通过在损伤部位周围提供一个微环境，并与生长因子或细胞相结合，3D打印支架有助于脊髓损伤后的轴突再生以及神经恢复。在此，我们概述了组织工程、3D打印支架、所使用的不同聚合物及其表征方法。本综述重点介绍了3D打印支架在开发新型脊髓损伤治疗方法方面最近令人鼓舞的应用。

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