Laboratory of Veterinary Pathology, Department of Veterinary Medicine, Nihon University, Kanagawa, Japan.
Bell Animal Hospital, Gifu, Japan.
J Vet Med Sci. 2022 Sep 12;84(9):1320-1323. doi: 10.1292/jvms.22-0267. Epub 2022 Jul 29.
A central bearded dragon (Pogona vitticeps) presented with periorbital swelling and exophthalmos. A retrobulbar mass was detected, and enucleation with the mass was performed. Histologically, the mass was composed of a dense sheet and interlacing bundles of round to polygonal to short spindle-shaped cells with occasional bizarre mononuclear and multinucleated giant cells. Immunohistochemically, the neoplastic cells had various degrees of membranous and/or cytoplasmic granular reactivity to anti-ionized calcium-binding adapter molecule 1 and anti-CD204 antibodies. Ultrastructurally, the neoplastic cells had irregular nuclei and abundant cytoplasm with membrane-bound electron-dense lysosomes and endoplasmic reticula. These findings were consistent with a histiocytic sarcoma. The present study provided a detailed description of retrobulbar histiocytic sarcoma for the first time in a central bearded dragon.
一只中央鬃狮蜥（Pogona vitticeps）出现眶周肿胀和眼球突出。检测到眶后有一个肿块，进行了眼球摘除术和肿块切除术。组织学上，肿块由密集的薄片和交织的圆形到多边形到短梭形细胞束组成，偶尔有奇异的单核和多核巨细胞。免疫组织化学染色显示，肿瘤细胞对离子钙结合衔接分子 1 和 CD204 抗体有不同程度的膜性和/或细胞质颗粒反应。超微结构上，肿瘤细胞的核不规则，细胞质丰富，有膜结合的电子致密溶酶体和内质网。这些发现与组织细胞肉瘤一致。本研究首次详细描述了中央鬃狮蜥的眶后组织细胞肉瘤。
