Kim Ji Yong, Mondaca-Ruff David, Singh Sandeep, Wang Yu
Department of Pharmacology and Pharmacy, The University of Hong Kong, Hong Kong SAR, China.
Front Endocrinol (Lausanne). 2022 Jul 14;13:930919. doi: 10.3389/fendo.2022.930919. eCollection 2022.
Autophagy is a cellular process involved in the selective degradation and recycling of dysfunctional intracellular components. It plays a crucial role in maintaining cellular homeostasis and survival by removing damaged and harmful proteins, lipids, and organelles. SIRT1, an NAD-dependent multifunctional enzyme, is a key regulator of the autophagy process. Through its deacetylase activity, SIRT1 participates in the regulation of different steps of autophagy, from initiation to degradation. The levels and function of SIRT1 are also regulated by the autophagy process. Dysregulation in SIRT1-mediated autophagy hinders the proper functioning of the endocrine system, contributing to the onset and progression of endocrine disorders. This review provides an overview of the crosstalk between SIRT1 and autophagy and their implications in obesity, type-2 diabetes mellitus, diabetic cardiomyopathy, and hepatic steatosis.
自噬是一种细胞过程，参与细胞内功能失调成分的选择性降解和循环利用。它通过清除受损和有害的蛋白质、脂质及细胞器，在维持细胞稳态和存活方面发挥关键作用。SIRT1是一种依赖烟酰胺腺嘌呤二核苷酸（NAD）的多功能酶，是自噬过程的关键调节因子。通过其脱乙酰酶活性，SIRT1参与自噬从起始到降解不同步骤的调节。SIRT1的水平和功能也受自噬过程的调控。SIRT1介导的自噬失调会阻碍内分泌系统的正常功能，导致内分泌紊乱的发生和发展。本综述概述了SIRT1与自噬之间的相互作用及其在肥胖、2型糖尿病、糖尿病性心肌病和肝脂肪变性中的意义。
