Wang Yuting, Lin Yao, Wang Hui, Li Yaqi, Shen Chen, Shi Lin
Department of Cardiology, Children's Hospital of Capital Institute of Pediatrics, No. 2, Yabao Road, Chaoyang District, Beijing, China.
Peking Union Medical College Graduate School, Beijing, China.
BMC Pediatr. 2025 Apr 30;25(1):340. doi: 10.1186/s12887-025-05671-z.
Decreased SIRT1 exhibits a correlation with a range of cardiovascular diseases. However, the changes in serum SIRT1 levels in pediatric primary hypertension have not been reported. This study aimed to investigate serum SIRT1 levels in pediatric primary hypertension and explore its association with left ventricular hypertrophy in the context of hypertension.
126 participants were recruited and categorized into the hypertensive group and the control group. Serum SIRT1 levels were comparatively investigated. Spearman correlation was utilized to establish an association between SIRT1 and blood pressure. Additionally, SIRT1 levels were comparative analyzed between the patients with and without left ventricular hypertrophy.
The case group had markedly decreased SIRT1 levels than the control group (p < 0.001), and a negative association between SIRT1 levels and blood pressure was revealed (p < 0.01). In subgroup analysis, patients with left ventricular hypertrophy exhibited notably reduced SIRT1 levels (p = 0.011). The multivariate logistic regression analysis showed that lower serum SIRT1 level was an independent risk factor for hypertension (OR = 0.447, 95% CI: 0.269-0.743, p = 0.002) and left ventricular hypertrophy (OR = 0.639, 95% CI: 0.486-0.840, p = 0.001).
Serum SIRT1 levels were significantly lower in pediatric primary hypertension patients and were negatively correlated with blood pressure. Patients with left ventricular hypertrophy had significantly lower serum SIRT1 levels, and decreased serum SIRT1 was an independent risk factor for left ventricular hypertrophy.
SIRT1水平降低与一系列心血管疾病相关。然而，小儿原发性高血压患者血清SIRT1水平的变化尚未见报道。本研究旨在调查小儿原发性高血压患者的血清SIRT1水平，并探讨其在高血压背景下与左心室肥厚的关系。
招募126名参与者，分为高血压组和对照组。对血清SIRT1水平进行比较研究。采用Spearman相关性分析来确定SIRT1与血压之间的关联。此外，对有和无左心室肥厚的患者的SIRT1水平进行比较分析。
病例组的SIRT1水平明显低于对照组（p<0.001），且SIRT1水平与血压呈负相关（p<0.01）。在亚组分析中，有左心室肥厚的患者SIRT1水平显著降低（p = 0.011）。多因素logistic回归分析显示，较低的血清SIRT1水平是高血压（比值比[OR]=0.447，95%置信区间[CI]：0.269-0.743，p = 0.002）和左心室肥厚（OR = 0.639，95% CI：0.486-0.840，p = 0.001）的独立危险因素。
小儿原发性高血压患者的血清SIRT1水平显著降低，且与血压呈负相关。有左心室肥厚的患者血清SIRT1水平显著降低，血清SIRT1降低是左心室肥厚的独立危险因素。
