Li Ting, Niu Shaowei, Qiu Xiang, Zhai Zhaohua, Yang Lin, Chen Li, Zhang Xiao Ming
The First Affiliated Hospital, Jinan University, Guangzhou, People's Republic of China.
Medical Imaging Key Laboratory of Sichuan Province, and Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, People's Republic of China.
Neuropsychiatr Dis Treat. 2022 Nov 10;18:2649-2659. doi: 10.2147/NDT.S386509. eCollection 2022.
To investigate cerebral blood flow (CBF) characteristics in individuals with generalized tonic‒clonic seizures (GTCS) during the interictal phase using voxel-based analysis of 3D pseudocontinuous arterial spin labeling (PCASL).
Patients with GTCS (GTCS group) (during the interictal period) and healthy volunteers (control group) underwent head MR imaging with a 3.0T MR scanner with a 3D PCASL sequence. CBF was compared between the two groups. Spearman correlations of CBF in regions of interest (ROIs) in GTCS patients with the duration of disease and age of onset were analyzed and corrected using the false discovery rate (FDR).
Twenty patients with GTCS (GTCS group) and twenty healthy volunteers (control group) were recruited for this study. On 3D PCASL, (1) GTCS patients had lower CBF in the brainstem, right cerebellum, right inferior temporal gyrus, parahippocampal gyrus, superior frontal gyrus, middle frontal gyrus, triangular part of inferior frontal gyrus, left temporal pole of superior temporal gyrus and thalamus and had higher CBF in the bilateral superior parietal gyri, precuneus, precentral gyri, postcentral gyri, and left dorsolateral superior frontal gyrus than controls. (2) The CBF of the right temporal pole of the middle temporal gyrus was negatively correlated with the duration of disease (P<0.05), with a correlation coefficient r of -0.7333 and a P value of 0.04.
Voxel-based analysis of 3D PCASL imaging can be used to sensitively detect brain perfusion differences in GTCS patients. The decrease in CBF in the right temporal pole of the middle temporal gyrus may be associated with disease onset. These findings may offer new perspectives on the pathogenesis of GTCS and the underlying pathophysiological changes associated with perfusion.
采用基于体素的三维伪连续动脉自旋标记（PCASL）分析，研究全面性强直阵挛发作（GTCS）患者发作间期的脑血流（CBF）特征。
GTCS患者（GTCS组）（发作间期）和健康志愿者（对照组）使用3.0T MR扫描仪及三维PCASL序列进行头部磁共振成像。比较两组的CBF。分析GTCS患者感兴趣区（ROI）的CBF与病程和发病年龄的Spearman相关性，并采用错误发现率（FDR）进行校正。
本研究招募了20例GTCS患者（GTCS组）和20名健康志愿者（对照组）。在三维PCASL上，（1）GTCS患者脑干、右侧小脑、右侧颞下回、海马旁回、额上回、额中回、额下回三角部、左侧颞上回颞极和丘脑的CBF较低，双侧顶上叶、楔前叶、中央前回、中央后回和左侧额上回背外侧的CBF高于对照组。（2）颞中回右侧颞极的CBF与病程呈负相关（P<0.05），相关系数r为-0.7333，P值为0.04。
基于体素的三维PCASL成像分析可用于灵敏检测GTCS患者的脑灌注差异。颞中回右侧颞极CBF降低可能与疾病发作有关。这些发现可能为GTCS的发病机制及与灌注相关的潜在病理生理变化提供新的视角。
