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佛罗里达州两个县与阿片类药物相关的过量致死病例

Opioid-Related Overdose Fatality Cases in Two Florida Counties.

作者信息

Powell Anne T, Bourgeois Marie M, Lichterman Julie, Johnson Giffe T, Galwankar Sagar, Harbison Raymond D

机构信息

Department of Environmental and Occupational Health, Center for Environmental and Occupational Risk Analysis and Management, College of Public Health, University of South Florida, Tampa, Florida, USA,FL USA.

Florida State University College of Medicine, Sarasota, FL USA.

出版信息

J Emerg Trauma Shock. 2022 Apr-Jun;15(2):83-87. doi: 10.4103/jets.jets_130_21. Epub 2022 Jun 27.

Abstract

INTRODUCTION

This study evaluates trends in drug-related death cases within both Pasco and Pinellas County, Florida, from the calendar years 2011 to 2016. Specifically, it focuses on opioids and the role of fentanyl in overdose-related mortality in rural versus suburban populations.

METHODS

Two sets of data from each calendar year were obtained from a Medical Examiner's Office. These data were compared by year to assess differences using the nonparametric ANOVA test with the statistical software SAS, University Edition. Binary logistic regression was performed to assess which drugs occurred most frequently in the presence or absence of fentanyl.

RESULTS

There was not a significant difference in the month of the year or the day of the week that drug-related fatalities occurred. More drug-related mortalities occurred during daylight hours (e.g., 8:00 AM-4:00 PM) and more fentanyl-related mortalities occurred in Pinellas County compared to Pasco County. Fentanyl and heroin tended to co-occur in mortalities, while ethanol, hydrocodone, morphine, oxycodone, and methadone were negatively associated with fentanyl-related overdose cases.

CONCLUSION

The characteristics of drug-related mortalities identified here may be used to better target interventions against drug abuse and overdose.

摘要

引言

本研究评估了2011年至2016日历年期间佛罗里达州帕斯科县和皮内拉斯县与药物相关的死亡案例趋势。具体而言,它关注阿片类药物以及芬太尼在农村和郊区人口过量用药相关死亡率中的作用。

方法

从法医办公室获取每个日历年的两组数据。使用统计软件SAS大学版的非参数方差分析测试按年份对这些数据进行比较,以评估差异。进行二元逻辑回归分析,以评估在有或没有芬太尼的情况下哪些药物出现的频率最高。

结果

与药物相关的死亡发生的月份或星期几没有显著差异。与药物相关的死亡更多发生在白天(例如上午8:00至下午4:00),与帕斯科县相比,皮内拉斯县与芬太尼相关的死亡更多。在死亡案例中,芬太尼和海洛因往往同时出现,而乙醇、氢可酮、吗啡、羟考酮和美沙酮与芬太尼相关的过量用药案例呈负相关。

结论

此处确定的与药物相关的死亡特征可用于更好地针对药物滥用和过量用药采取干预措施。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbfc/9336642/6cbca634e024/JETS-15-83-g001.jpg

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