富血小板血浆治疗小关节介导的下腰痛：一项综合综述
Platelet-Rich Plasma in the Treatment of Facet Mediated Low Back Pain: A Comprehensive Review.
作者信息
Patel Aakash, Koushik Sarang, Schwartz Ruben, Gritsenko Karina, Farah Fadi, Urits Ivan, Varrassi Giustino, Viswanath Omar, Shaparin Naum
机构信息
Montefiore Medical Center, Albert Einstein School of Medicine.
Valleywise Health Medical Center, Creighton University School of Medicine.
出版信息
Orthop Rev (Pavia). 2022 Jul 27;14(4):37076. doi: 10.52965/001c.37076. eCollection 2022.
BACKGROUND
Facet-mediated pain is a major cause of low back pain and as a result, is a significant cause of morbidity, including disability and reduced functionality.
SETTING
The present investigation involved a PubMed literature review between June 1, and 2021-January 1, 2022.
METHODS
We systematically reviewed was carried Pubmed using the search terms "platelet-rich plasma", "inflammatory mediators", "facet arthropathy", "axial back pain", and "leukoreduction". Data extraction and quality assessment were performed by 3 independent reviewers. Out of the studies analyzed 2 were retrospective, while 1 was a prospective study.
RESULTS
PRP injections for facet mediated or modulated pain are an alternative to conventional pharmacotherapies and interventional injections/radiofrequency. There are limited numbers of studies in world literature at present.
LIMITATIONS
Small number of articles in the world literature and small numbers of patients in those published studies.
CONCLUSIONS
At present, there are limited studies in the literature; however, larger well-designed studies are warranted to precisely understand efficacy, potential side effects and best practice techniques for PRP injections for facet mediated or modulated pain.
背景
小关节介导的疼痛是下腰痛的主要原因，因此也是包括残疾和功能下降在内的发病率的重要原因。
背景
本研究涉及2021年6月1日至2022年1月1日期间的PubMed文献综述。
方法
我们使用搜索词“富血小板血浆”、“炎症介质”、“小关节病”、“轴性背痛”和“白细胞去除术”对PubMed进行了系统综述。数据提取和质量评估由3名独立审稿人进行。在分析的研究中，2项为回顾性研究，1项为前瞻性研究。
结果
用于小关节介导或调节性疼痛的富血小板血浆注射是传统药物治疗和介入注射/射频治疗的替代方法。目前世界文献中的研究数量有限。
局限性
世界文献中的文章数量少，且已发表研究中的患者数量少。
结论
目前，文献中的研究有限；然而，需要进行更大规模、设计良好的研究，以准确了解富血小板血浆注射治疗小关节介导或调节性疼痛的疗效、潜在副作用和最佳实践技术。
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