Chakraborty Biswajit, Mukerjee Nobendu, Maitra Swastika, Zehravi Mehrukh, Mukherjee Dattatreya, Ghosh Arabinda, Massoud Ehab El Sayed, Rahman Md Habibur
Department of Biochemistry and Biophysics, University of Kalyani, Nadia, West Bengal, India.
Department of Microbiology, Ramakrishna Mission Vivekananda Centenary College, West Bengal, India.
Oxid Med Cell Longev. 2022 Jul 22;2022:6873874. doi: 10.1155/2022/6873874. eCollection 2022.
A high incidence of dementia (60-80%) and a high rate of memory loss are two of the most common symptoms of Alzheimer's disease (AD), which affects the elderly. Researchers have recommended that traditional Chinese medicine (TCM) and Indian medicines can be used to prevent and cure AD. Several studies have linked neuroinflammation linked to amyloid- (A) deposition in the brain to the pathophysiology of neurodegenerative disorders. As a result, more research is needed to determine the role of inflammation in neurodegeneration. Increased microglial activation, cytokine production, reactive oxygen species (ROS), and nuclear factor kappa B (NF-B) all play a role in the inflammatory process of AD. This review focuses on the role of neuroinflammation in neuroprotection and the molecular processes used by diverse natural substances, phytochemicals, and herbal formulations in distinct signaling pathways. Currently, researchers are focusing on pharmacologically active natural compounds with the anti-neuroinflammatory potential, making them a possible contender for treating AD. Furthermore, the researchers investigated the limits of past studies on TCM, Indian Ayurveda, and AD. Numerous studies have been carried out to examine the effects of medicinal whole-plant extracts on AD. Clinical investigations have shown that lignans, flavonoids, tannins, polyphenols, triterpenoids, sterols, and alkaloids have anti-inflammatory, antiamyloidogenic, anticholinesterase, and antioxidant properties. This review summarizes information about numerous medicinal plants and isolated compounds used in the treatment of AD and a list of further references.
痴呆症的高发病率（60 - 80%）和高失忆率是阿尔茨海默病（AD）最常见的两种症状，该病影响老年人。研究人员建议，中药和印度药可用于预防和治疗AD。多项研究已将与大脑中淀粉样蛋白（A）沉积相关的神经炎症与神经退行性疾病的病理生理学联系起来。因此，需要更多研究来确定炎症在神经退行性变中的作用。小胶质细胞活化增加、细胞因子产生、活性氧（ROS）和核因子κB（NF - B）均在AD的炎症过程中起作用。本综述聚焦于神经炎症在神经保护中的作用，以及不同天然物质、植物化学物和草药制剂在不同信号通路中所采用的分子过程。目前，研究人员正专注于具有抗神经炎症潜力的药理活性天然化合物，使其成为治疗AD的可能候选物。此外，研究人员还研究了以往关于中药、印度阿育吠陀医学与AD研究的局限性。已经开展了大量研究来检验药用全植物提取物对AD的影响。临床研究表明，木脂素、黄酮类化合物、单宁、多酚、三萜类化合物、甾醇和生物碱具有抗炎、抗淀粉样蛋白生成、抗胆碱酯酶和抗氧化特性。本综述总结了有关用于治疗AD的多种药用植物和分离化合物的信息以及进一步的参考文献列表。
