Antonios Bana, Zimmer Markie, Herrman Emma, Berghea Ramona
Department of Internal Medicine, William Beaumont Hospital, Royal Oak, MI, USA.
Case Rep Hematol. 2022 Jul 27;2022:7208401. doi: 10.1155/2022/7208401. eCollection 2022.
Immune thrombocytopenia (ITP) has been associated with immunizations with various proposed mechanisms, including overactivation of the immune system and production of antibodies against circulating platelets. ITP has also been associated with several viral infections, including HCV, HIV, and most recently, active SARS-CoV-2 infection. Here, we present a case of a 52-year-old male with no past medical history who sought evaluation with his primary care physician for upper and lower extremity ecchymosis of one week duration. Outpatient laboratory studies were notable for severe isolated thrombocytopenia with platelet count of 8 × 109/L. Interestingly, he received the Johnson and Johnson COVID-19 vaccine 16 days prior to his presentation. Clinical work up and laboratory investigations led to the diagnosis of ITP.
免疫性血小板减少症（ITP）与多种免疫接种相关，存在多种可能机制，包括免疫系统过度激活以及产生针对循环血小板的抗体。ITP还与多种病毒感染有关，包括丙型肝炎病毒（HCV）、人类免疫缺陷病毒（HIV），以及最近的新型冠状病毒严重急性呼吸综合征（SARS-CoV-2） 活跃感染。在此，我们报告一例52岁男性病例，该患者既往无病史，因持续一周的上下肢瘀斑就诊于其初级保健医生处。门诊实验室检查显示严重的单纯性血小板减少症，血小板计数为8×10⁹/L。有趣的是，他在就诊前16天接种了强生公司的新冠疫苗。临床检查和实验室调查最终诊断为ITP。
