Xu Yongli, Zeng Fanqiang, Jiang Jianping, Huo Juan, Zhao Chengjian, Yan Zhigang, Li Li
Guangxi Botanical Garden of Medicinal Plants, Nanning 530023, Guangxi, China.
Department of Pharmacy, Guigang City People's Hospital, The Eighth Affiliated Hospital of Guangxi Medical University, Guigang 537100, Guangxi, China.
Evid Based Complement Alternat Med. 2022 Jul 19;2022:1025504. doi: 10.1155/2022/1025504. eCollection 2022.
Maoji Jiu (MJ), a medicinal wine, has been used commonly by the Chinese to enrich and nourish the blood. In this study, the aim is to examine the hematopoietic function of MJ and investigate its hematopoietic regulation mechanism. Thirty-six female Sprague-Dawley rats (200 ± 20 g) were randomly divided into six groups with six rats in each group. The blood deficiency model was induced by injecting hypodermically with N-acetylphenylhydrazine (APH) and injecting intraperitoneally with cyclophosphamide (CTX), and treatment drugs were given by oral gavage twice a day for continuous 10 days from the start of the experiments. The administration of MJ improved the levels of white blood cells (WBCs), red blood cells (RBCs), hemoglobin (HGB), and hematocrit (HCT) in the blood deficiency model rats. Hematopoietic effect involves regulating the antioxidant activity in the liver and the levels of Bcl-2, Bax, erythropoietin (EPO), transforming growth factor-beta-1 (TGF-1), and macrophage colony-stimulating factor (M-CSF) mRNA in spleen tissues to enhance extramedullary hematopoiesis. This study suggests that MJ has a beneficial effect on blood deficiency model rats.
毛鸡酒（MJ）是一种药酒，中国人常用它来补血养血。在本研究中，目的是检测毛鸡酒的造血功能并探究其造血调节机制。将36只雌性Sprague-Dawley大鼠（200 ± 20 g）随机分为6组，每组6只。通过皮下注射N-乙酰苯肼（APH）和腹腔注射环磷酰胺（CTX）诱导血虚模型，并从实验开始每天经口灌胃给药治疗药物2次，持续10天。毛鸡酒给药提高了血虚模型大鼠血液中白细胞（WBC）、红细胞（RBC）、血红蛋白（HGB）和血细胞比容（HCT）的水平。造血作用涉及调节肝脏中的抗氧化活性以及脾脏组织中Bcl-2、Bax、促红细胞生成素（EPO）、转化生长因子-β1（TGF-1）和巨噬细胞集落刺激因子（M-CSF）mRNA的水平，以增强髓外造血。本研究表明毛鸡酒对血虚模型大鼠有有益作用。
