Department of Oral Pathology, Oral Cancer Research Institute, Yonsei University College of Dentistry, Seoul, South Korea.
Department of Oral and Maxillofacial Surgery, Yonsei University College of Dentistry, Seoul, South Korea.
Pathol Oncol Res. 2022 Jul 14;28:1610352. doi: 10.3389/pore.2022.1610352. eCollection 2022.
Salivary gland tumor Sialadenoma papilliferum (SialP) clinically resembles papillary epithelial lesions, such as squamous papilloma (SqP) or verrucous leukoplakia. Pathological sampling including an adequate depth of both the mucosa and submucosa layer is required for discrimination between the diseases. Though ductal proliferation in the submucosa is characteristic in SialP, papillary lesions arising at the mouth floor, specifically near the ductal orifice, are more problematic. Salivary gland ductal ectasia, along with the overlying papillary hyperplasia, may mimic the biphasic tumorous growth pattern of SialP, making discrimination extremely difficult. Further cellular dysplasia in the papillary mucosal lesion raises the possibility of malignant transformation in a known benign lesion, SialP. Herein, we present a case of SqP at the mouth floor which mimicked both clinical and pathological features of SialP and compared it with a definite case of SialP. Moreover, we discuss major differential points that clinicians and pathologists should consider during diagnosis of oral papillary lesions arising near the salivary glands.
涎腺肿瘤涎腺乳头瘤（SialP）临床上类似于乳头状上皮病变，如鳞状乳头状瘤（SqP）或疣状白斑。鉴别这些疾病需要包括黏膜和黏膜下层足够深度的病理性取样。虽然 SialP 的特征是黏膜下的导管增生，但口腔底部（特别是靠近导管口的部位）出现的乳头状病变则更具挑战性。涎腺导管扩张，加上其上的乳头状增生，可能会模拟 SialP 的双相肿瘤生长模式，使得鉴别变得极其困难。乳头状黏膜病变中的进一步细胞异型增生增加了已知良性病变 SialP 发生恶性转化的可能性。在此，我们报告了一个口腔底部的 SqP 病例，该病例既具有 SialP 的临床特征，也具有病理特征，并将其与明确的 SialP 病例进行了比较。此外，我们讨论了临床医生和病理学家在诊断涎腺附近发生的口腔乳头状病变时应考虑的主要鉴别点。
