Hashmi Atif Ali, Hussain Zubaida Fida, Hashmi Shumaila Kanwal, Irfan Muhammad, Khan Erum Yousuf, Faridi Naveen, Khan Amir, Edhi Muhammad Muzzammil
Liaquat National Hospital and Medical College, Karachi, Pakistan.
CMH Multan Institute of Medical Sciences, Multan, Pakistan.
BMC Res Notes. 2018 Jul 3;11(1):433. doi: 10.1186/s13104-018-3547-7.
Immunohistochemical over expression of p53 is considered as a marker of poor prognosis in many cancers. Therefore, we aimed to evaluate immunohistochemical overexpression of p53 in 121 cases of head and neck Squamous cell carcinoma and its association with various clinicopathologic features and survival.
Total 66.1% (80 cases) expressed positive p53 expression, 34% (29 cases) revealed no p53 expression, while focal positive p53 expression was noted in 9.9% (12 Cases). Moreover, high p53 expression (> 70%) was noted in 26.4% (32 cases), while 19% (23 cases) showed 51-70% p53 expression. On the basis of intensity of p53 staining; strong p53 expression was noted in 39.7% (48 cases), while 24.8% (30 cases) and 10.7% (13 cases) revealed intermediate and weak p53 expression respectively. Significant association of p53 intensity of expression with extranodal extension and higher tumor grade (grades II and III) was noted. p53 is useful prognostic biomarker in head and neck Squamous cell carcinoma and therefore we suggest that more large scale studies are needed to evaluate its prognostic significance in our population.
在许多癌症中，p53的免疫组化过表达被认为是预后不良的标志物。因此，我们旨在评估121例头颈部鳞状细胞癌中p53的免疫组化过表达情况及其与各种临床病理特征和生存率的关系。
总计66.1%（80例）p53表达呈阳性，34%（29例）未检测到p53表达，而9.9%（12例）为局灶性p53阳性表达。此外，26.4%（32例）p53高表达（>70%），19%（23例）p53表达为51%-70%。根据p53染色强度；39.7%（48例）为强p53表达，24.8%（30例）和10.7%（13例）分别为中度和弱p53表达。p53表达强度与结外扩展及较高肿瘤分级（II级和III级）存在显著相关性。p53是头颈部鳞状细胞癌有用的预后生物标志物，因此我们建议需要更多大规模研究来评估其在我们人群中的预后意义。
