Department of Psychiatry, Department of Neuroscience and Physiology, Neuroscience Institute, New York University School of Medicine, New York, NY, United States.
Department of Neurosurgery, Xinqiao Hospital, Army Medical University, Chongqing, China.
Front Neural Circuits. 2022 Jul 14;16:924016. doi: 10.3389/fncir.2022.924016. eCollection 2022.
Grid cells or grid-like responses have been reported in the rodent, bat and human brains during various spatial and non-spatial tasks. However, the functions of grid-like representations beyond the classical hippocampal formation remain elusive. Based on accumulating evidence from recent rodent recordings and human fMRI data, we make speculative accounts regarding the mechanisms and functional significance of the sensory cortical grid cells and further make theory-driven predictions. We argue and reason the rationale why grid responses may be universal in the brain for a wide range of perceptual and cognitive tasks that involve locomotion and mental navigation. Computational modeling may provide an alternative and complementary means to investigate the grid code or grid-like map. We hope that the new discussion will lead to experimentally testable hypotheses and drive future experimental data collection.
网格细胞或类似网格的反应已在啮齿动物、蝙蝠和人类大脑中报告，在各种空间和非空间任务中。然而，经典海马体以外的类似网格的表示形式的功能仍然难以捉摸。基于最近啮齿动物记录和人类 fMRI 数据的累积证据，我们对感觉皮层网格细胞的机制和功能意义进行了推测性的解释，并进一步做出了理论驱动的预测。我们认为并论证了网格反应可能在大脑中对于广泛的涉及运动和心理导航的感知和认知任务具有普遍性的基本原理。计算模型可能为研究网格代码或类似网格的地图提供一种替代和互补的手段。我们希望新的讨论将导致可进行实验测试的假设，并推动未来的实验数据收集。
