Lindström-Seppä P, Pesonen M
Acta Biol Hung. 1986;37(1):85-92.
Biotransformation in fish--as in mammals--is catalyzed by several enzymes. These convert liposoluble endogenous and exogenous substrates to more water-soluble compounds prior to excretion. The biotransformation enzymes are induced by environmental pollutants. The induction can be expected to precede the onset of more serious changes at higher organization levels. We have studied the effect of petroleum from a ship spill and bleached kraft mill effluent on hepatic biotransformation enzyme activities of local fish species perch (Perca fluviatilis) and vedace (Coregonus albula) in Finland. Four months after the petroleum spill an elevated level of monoxygenase as well as glutathione S-transferase enzyme activities was seen in perch. Afterwards the difference between the control perch and the exposed ones disappeared. Bleached kraft mill effluent had effect on hepatic biotransformation in vendace. Increasing exposure time and effluent concentration elevated the activities.
鱼类的生物转化——与哺乳动物一样——由几种酶催化。这些酶在排泄之前将脂溶性的内源性和外源性底物转化为水溶性更强的化合物。生物转化酶由环境污染物诱导产生。预计这种诱导会在更高组织水平上出现更严重变化之前发生。我们研究了芬兰一艘油轮泄漏的石油和漂白硫酸盐制浆厂废水对当地鱼类鲈鱼（河鲈）和白鱼（白鲑）肝脏生物转化酶活性的影响。石油泄漏四个月后，鲈鱼体内的单加氧酶以及谷胱甘肽S-转移酶的活性水平升高。之后，对照鲈鱼和受污染鲈鱼之间的差异消失了。漂白硫酸盐制浆厂废水对白鱼的肝脏生物转化有影响。暴露时间和废水浓度的增加会提高酶的活性。
