Wei Sen, Yuan Xin, Li Dongdong, Guo Xinbin, Guan Sheng, Xu Yuming
Department of Neurointervention, The First Affiliated Hospital of Zhengzhou University at Zhengzhou, Zhengzhou, China.
Department of Neurology, The First Affiliated Hospital of Zhengzhou University at Zhengzhou, Zhengzhou, China.
Front Neurosci. 2022 Jul 14;16:945537. doi: 10.3389/fnins.2022.945537. eCollection 2022.
Homocysteine (Hcy) levels may be associated with the development of intracranial aneurysms (IAs). However, whether it increases the risk of rupture of IAs is unknown. This study aimed to determine the association between homocysteine levels and IA rupture.
We retrospectively reviewed patients with IAs and subarachnoid hemorrhage (SAH) at our hospital between January 2019 and May 2021. Clinical data, including Hcy levels and IA images, were assessed. The association between Hcy level and IA rupture was investigated using multivariate logistic regression analyses in patients with IAs and SAH.
A total of 589 patients were included. 546 patients with IAs, including 331 UIA (Unruptured IA) and 215 RIA (Ruptured IA). The average age was 57.43 ± 10.86 years old, and 67.03% were women. Among them, all 215 RIAs lead to SAH. In addition, we also enrolled 43 non-aneurysmal subarachnoid hemorrhage (Na-SAH) patients. The average age was 54.12 ± 10.55 years old, and 53.48% were female. After adjusting for confounders in the multivariate model, Hcy levels were correlated with the rupture of IA (odds ratio [OR] 1.069; 95% confidence interval [CI] 1.025-1.114, = 0.002) and a-SAH (OR 1.083; 95% CI 1.002-1.170, = 0.046).
Hcy levels were associated with IA rupture. These findings provide novel insights into IAs rupture, and future studies are needed to confirm this relationship.
同型半胱氨酸（Hcy）水平可能与颅内动脉瘤（IA）的发生有关。然而，其是否会增加IA破裂的风险尚不清楚。本研究旨在确定同型半胱氨酸水平与IA破裂之间的关联。
我们回顾性分析了2019年1月至2021年5月期间我院收治的IA和蛛网膜下腔出血（SAH）患者。评估了包括Hcy水平和IA影像在内的临床资料。采用多因素logistic回归分析研究IA和SAH患者中Hcy水平与IA破裂之间的关联。
共纳入589例患者。546例IA患者，包括331例未破裂IA（UIA）和215例破裂IA（RIA）。平均年龄为57.43±10.86岁，67.03%为女性。其中，所有215例RIA均导致SAH。此外，我们还纳入了43例非动脉瘤性蛛网膜下腔出血（Na-SAH）患者。平均年龄为54.12±10.55岁，53.48%为女性。在多因素模型中校正混杂因素后，Hcy水平与IA破裂（比值比[OR]1.069；95%置信区间[CI]1.025-1.114，P = 0.002）和a-SAH（OR 1.083；95%CI 1.002-1.170，P = 0.046）相关。
Hcy水平与IA破裂有关。这些发现为IA破裂提供了新的见解，未来需要进一步研究来证实这种关系。
