Palomba Stefano, Falbo Angela I, Marci Roberto, Caserta Donatella
Department of Obstetrics and Gynecology, Magna Graecia University of Catanzaro, Catanzaro, Italy -
Arcispedale S. Maria Nuova of Reggio Emilia, Reggio Emilia, Italy.
Minerva Obstet Gynecol. 2023 Apr;75(2):172-180. doi: 10.23736/S2724-606X.22.05144-2. Epub 2022 Aug 1.
Women with polycystic ovary syndrome (PCOS) seem to have impaired reproductive performances. It is generally considered that an altered ovulatory function is the main cause of infertility in the affected women. However, other factors may play a role in the pathogenesis of the PCOS-related infertility. During the last years, more and more importance has been given to endometrium as contributor of the PCOS-related subfertility. In the present narrative review, the main and recent experimental and clinical data will discuss in order to clarify the role played by the endometrium in the PCOS-related subfertility. The overall analysis of available data suggests that, in women with PCOS, the endometrium is primarily affected, and closely and deeply influenced by the several hormonal, metabolic, clinical alterations related to the syndrome.
患有多囊卵巢综合征（PCOS）的女性似乎生殖能力受损。一般认为，排卵功能改变是受影响女性不孕的主要原因。然而，其他因素可能在PCOS相关不孕的发病机制中起作用。在过去几年中，子宫内膜作为PCOS相关生育力低下的一个因素越来越受到重视。在本叙述性综述中，将讨论主要的和最新的实验及临床数据，以阐明子宫内膜在PCOS相关生育力低下中所起的作用。对现有数据的综合分析表明，在PCOS女性中，子宫内膜首先受到影响，并受到与该综合征相关的多种激素、代谢和临床改变的密切和深刻影响。
